Evidence map›Paper›PMID 25569869›Full record

ArticleOrganic & biomolecular chemistry2015

Regulating exocytosis of nanoparticles via host-guest chemistry.

Chaekyu Kim, Gulen Yesilbag Tonga, Bo Yan, Chang Soo Kim, Sung Tae Kim, Myoung-Hwan Park, Zhengjiang Zhu, Bradley Duncan, Brian Creran, Vincent M Rotello

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic & biomolecular chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Exocytosis of Nanoparticles: A Comprehensive Review.Nanomaterials (Basel, Switzerland) · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Cancer Cell Discrimination Using Host-Guest "Doubled" Arrays.Journal of the American Chemical Society · 2017
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chaekyu Kim *Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Gulen Yesilbag Tonga *Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Bo YanDepartment of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Chang Soo KimDepartment of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Sung Tae KimDepartment of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Myoung-Hwan ParkDepartment of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Zhengjiang ZhuDepartment of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Bradley DuncanDepartment of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Brian CreranDepartment of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Vincent M RotelloDepartment of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.

Funding

Intracellular Host-Guest Activation of Nanoparticle TherapeuticsR01EB014277 · NIBIB · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTELLO, VINCENT M. · 2012 to 2014
$1.0M
NIBIB NIH HHS R01 EB014277NIBIB NIH HHS R01 EB014277-01
6 · The paper itself

Abstract

Prolonged retention of internalized nanoparticulate systems inside cells improves their efficacy in imaging, drug delivery, and theranostic applications. Especially, regulating exocytosis of the nanoparticles is a key factor in the fabrication of effective nanocarriers for chemotherapeutic treatments but orthogonal control of exocytosis in the cellular environment is a major challenge. Herein, we present the first example of regulating exocytosis of gold nanoparticles (AuNPs), a model drug carrier, by using a simple host-guest supramolecular system. AuNPs featuring quaternary amine head groups were internalized into the cells through endocytosis. Subsequent in situ treatment of a complementary cucurbit[7]uril (CB[7]) to the amine head groups resulted in the AuNP-CB[7] complexation inside cells, rendering particle assembly. This complexation induced larger particle assemblies that remained sequestered in the endosomes, inhibiting exocytosis of the particles without any observed cytotoxicity.

Indexed as

ExocytosisAminesBridged-Ring CompoundsCucurbit(n)urilsDrug CarriersEndosomesGoldHumansImidazolesMacrocyclic CompoundsMCF-7 CellsMetal NanoparticlesAminesBridged-Ring Compoundscucurbit(7)urilCucurbit(n)urilsDrug CarriersGoldImidazolesMacrocyclic Compounds

Identifiers

PMID25569869
PMCPMC4323993

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.