ArticlePLoS genetics2015
A genetic strategy for probing the functional diversity of magnetosome formation.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 79 citations in OpenAlex.
- Biosynthesis and function of magnetic organelles in magnetotactic bacteria.Nature reviews. Microbiology · 2026Review
- A network of coiled-coil and actin-like proteins controls the cellular organization of magnetosome organelles in deep-branching magnetotactic bacteria.Nature communications · 2025Article
- A network of coiled-coil and actin-like proteins controls the cellular organization of magnetosome organelles in deep-branching magnetotactic bacteria.bioRxiv : the preprint server for biology · 2025Article
- Organizing organelles: bacterial strategies for localizing intracellular compartments.Current opinion in microbiology · 2025Review
- Linking morphology, genome, and metabolic activity of uncultured magnetotactic Nitrospirota at the single-cell level.Microbiome · 2024Article
- Key gene networks that control magnetosome biomineralization in magnetotactic bacteria.National science review · 2023Article
- Article
- Magnetotactic bacteria and magnetofossils: ecology, evolution and environmental implications.NPJ biofilms and microbiomes · 2022Review
- New Phenotype and Mineralization of Biogenic Iron Oxide in Magnetotactic Bacteria.Nanomaterials (Basel, Switzerland) · 2021Article
- Identification and Genomic Characterization of Two Previously Unknown MagnetotacticFrontiers in microbiology · 2021Article
- Genome-Wide Identification of Essential and Auxiliary Gene Sets for Magnetosome Biosynthesis in Magnetospirillum gryphiswaldense.mSystems · 2020Article
- Expanding magnetic organelle biogenesis in the domain Bacteria.Microbiome · 2020Article
- Bacterial genetics and molecular pathogenesis in the age of high throughput DNA sequencing.Current opinion in microbiology · 2020Review
- Magnetic genes: Studying the genetics of biomineralization in magnetotactic bacteria.PLoS genetics · 2020Review
- Anion transport as a target of adaption to perchlorate in sulfate-reducing communities.The ISME journal · 2020Article
- Designer Sinorhizobium meliloti strains and multi-functional vectors enable direct inter-kingdom DNA transfer.PloS one · 2019Article
- Genome Editing Method for the Anaerobic Magnetotactic Bacterium Desulfovibrio magneticus RS-1.Applied and environmental microbiology · 2018Article
- Potential of metabolic engineering in bacterial nanosilver synthesis.World journal of microbiology & biotechnology · 2018Review
- Localized iron accumulation precedes nucleation and growth of magnetite crystals in magnetotactic bacteria.Scientific reports · 2017Article
- Genomic sequencing-based mutational enrichment analysis identifies motility genes in a genetically intractable gut microbe.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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9 authors at 4 institutions in 2 countries.
Funding
Abstract
Model genetic systems are invaluable, but limit us to understanding only a few organisms in detail, missing the variations in biological processes that are performed by related organisms. One such diverse process is the formation of magnetosome organelles by magnetotactic bacteria. Studies of model magnetotactic α-proteobacteria have demonstrated that magnetosomes are cubo-octahedral magnetite crystals that are synthesized within pre-existing membrane compartments derived from the inner membrane and orchestrated by a specific set of genes encoded within a genomic island. However, this model cannot explain all magnetosome formation, which is phenotypically and genetically diverse. For example, Desulfovibrio magneticus RS-1, a δ-proteobacterium for which we lack genetic tools, produces tooth-shaped magnetite crystals that may or may not be encased by a membrane with a magnetosome gene island that diverges significantly from those of the α-proteobacteria. To probe the functional diversity of magnetosome formation, we used modern sequencing technology to identify hits in RS-1 mutated with UV or chemical mutagens. We isolated and characterized mutant alleles of 10 magnetosome genes in RS-1, 7 of which are not found in the α-proteobacterial models. These findings have implications for our understanding of magnetosome formation in general and demonstrate the feasibility of applying a modern genetic approach to an organism for which classic genetic tools are not available.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.