Creating diversified response profiles from a single quenchometric sensor element by using phase-resolved luminescence.

Elizabeth C Tehan, Rachel M Bukowski, Vamsy P Chodavarapu, Albert H Titus, Alexander N Cartwright, Frank V Bright

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Article in Sensors (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Elizabeth C TehanDepartment of Chemistry, Natural Sciences Complex, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA. cornell.elizabeth@yahoo.com.

Rachel M BukowskiDepartment of Chemistry, Natural Sciences Complex, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA. rmbukowski@gmail.com.

Vamsy P ChodavarapuDepartment of Electrical and Computer Engineering, McGill University, McConnell Engineering Building, 3480 University Street, Montreal, QC H3A 0E9, Canada. vamsy.chodavarapu@mcgill.ca.

Albert H TitusDepartment of Electrical Engineering, Bonner Hall, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA. ahtitus@buffalo.edu.

Alexander N CartwrightDepartment of Electrical Engineering, Bonner Hall, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA. anc@buffalo.edu.

Frank V BrightDepartment of Chemistry, Natural Sciences Complex, University at Buffalo, The State University of New York, Buffalo, NY 14260, USA. chefvb@buffalo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a new strategy for generating a continuum of response profiles from a single luminescence-based sensor element by using phase-resolved detection. This strategy yields reliable responses that depend in a predictable manner on changes in the luminescent reporter lifetime in the presence of the target analyte, the excitation modulation frequency, and the detector (lock-in amplifier) phase angle. In the traditional steady-state mode, the sensor that we evaluate exhibits a linear, positive going response to changes in the target analyte concentration. Under phase-resolved conditions the analyte-dependent response profiles: (i) can become highly non-linear; (ii) yield negative going responses; (iii) can be biphasic; and (iv) can exhibit super sensitivity (e.g., sensitivities up to 300 fold greater in comparison to steady-state conditions).

Identifiers

PMID25569752

DOI10.3390/s150100760

PMCPMC4327047

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LicenceCC BY

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