ArticleNature communications2015
Maturation of the HIV-1 core by a non-diffusional phase transition.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- HIV Genome-Wide Protein Associations: a Review of 30 Years of Research.Microbiology and molecular biology reviews : MMBR · 2016Pooled it
- Mechanisms of HIV-1 assembly, release and maturation.Nature reviews. Microbiology · 2026Review
- HIV-1 capsid and viral DNA integration.mBio · 2024Review
- Critical mechanistic features of HIV-1 viral capsid assembly.Science advances · 2023Article
- Article
- Review
- Rotten to the core: antivirals targeting the HIV-1 capsid core.Retrovirology · 2021Review
- Maturation of the matrix and viral membrane of HIV-1.Science (New York, N.Y.) · 2021Article
- Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms.Cell host & microbe · 2019Article
- Maturation of retroviruses.Current opinion in virology · 2019Review
- Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle.Virologica Sinica · 2019Review
- Mechanical characterization of HIV-1 with a solid-state nanopore sensor.Electrophoresis · 2019Article
- Structure and architecture of immature and mature murine leukemia virus capsids.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- High-resolution structures of HIV-1 Gag cleavage mutants determine structural switch for virus maturation.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Recent advances in retroviruses via cryo-electron microscopy.Retrovirology · 2018Review
- Quenching protein dynamics interferes with HIV capsid maturation.Nature communications · 2017Article
- Patterns of conserved gp120 epitope presentation on attached HIV-1 virions.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- In vitro assembly of the Rous Sarcoma Virus capsid protein into hexamer tubes at physiological temperature.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
The formation of the HIV-1 core is the final step in the viral maturation pathway, resulting in the formation of infectious virus. Most current models for HIV-1 core formation suggest that, upon proteolytic cleavage from the immature Gag, capsid (CA) dissociates into the viral interior before reforming into the core. Here we present evidence for an alternate view of core formation by taking advantage of our serendipitous observation of large membrane-enclosed structures in HIV-1 supernatants from infected cells. Cryo-electron tomographic studies show that these structures, which contain ordered arrays of what is likely the membrane-associated matrix protein, contain multiple cores that can be captured at different stages of maturation. Our studies suggest that HIV maturation involves a non-diffusional phase transition in which the detaching layer of the cleaved CA lattice is gradually converted into a roll that ultimately forms the surface of the mature conical core.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.