ArticlePLoS computational biology2015
A computational framework for 3D mechanical modeling of plant morphogenesis with cellular resolution.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 50 papers.
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50 citing papers in PubMed, 148 citations in OpenAlex.
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- Ontogeny of collective behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Localized growth and remodelling drives spongy mesophyll morphogenesis.Journal of the Royal Society, Interface · 2022Article
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
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- What shoots can teach about theories of plant form.Nature plants · 2021Review
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- A field theory for plant tropisms.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Shaping the Organ: A Biologist Guide to Quantitative Models of Plant Morphogenesis.Frontiers in plant science · 2021Review
- Primary Cell Wall Modifying Proteins Regulate Wall Mechanics to Steer Plant Morphogenesis.Frontiers in plant science · 2021Review
- Dynamical Modeling of the Core Gene Network Controlling Transition to Flowering inFrontiers in genetics · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The link between genetic regulation and the definition of form and size during morphogenesis remains largely an open question in both plant and animal biology. This is partially due to the complexity of the process, involving extensive molecular networks, multiple feedbacks between different scales of organization and physical forces operating at multiple levels. Here we present a conceptual and modeling framework aimed at generating an integrated understanding of morphogenesis in plants. This framework is based on the biophysical properties of plant cells, which are under high internal turgor pressure, and are prevented from bursting because of the presence of a rigid cell wall. To control cell growth, the underlying molecular networks must interfere locally with the elastic and/or plastic extensibility of this cell wall. We present a model in the form of a three dimensional (3D) virtual tissue, where growth depends on the local modulation of wall mechanical properties and turgor pressure. The model shows how forces generated by turgor-pressure can act both cell autonomously and non-cell autonomously to drive growth in different directions. We use simulations to explore lateral organ formation at the shoot apical meristem. Although different scenarios lead to similar shape changes, they are not equivalent and lead to different, testable predictions regarding the mechanical and geometrical properties of the growing lateral organs. Using flower development as an example, we further show how a limited number of gene activities can explain the complex shape changes that accompany organ outgrowth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.