Evidence map›Paper›PMID 25569396›Full record

ArticleThe Journal of craniofacial surgery2015

Effects of open and endoscopic surgery on skull growth and calvarial vault volumes in sagittal synostosis.

Rahel G Ghenbot, Kamlesh B Patel, Gary B Skolnick, Sybill D Naidoo, Matthew D Smyth, Albert S Woo

Open access · greenAbstract readComparative StudyControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of craniofacial surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Endoscopic versus open approach in craniosynostosis repair: a systematic review and meta-analysis of perioperative outcomes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2018
    Pooled it
  3. Spring-mediated cranioplasty for scaphocephaly: techniques and outcomes.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
    Article
  4. Long-term outcome in 415 operated cases with single suture scaphocephaly.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  5. Review
  6. Endoscopic-assisted repair for sagittal synostosis.Neurosurgical focus: Video · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rahel G GhenbotFrom the *Division of Plastic and Reconstructive Surgery, Cleft Palate-Craniofacial Institute, and †Department of Neurosurgery, Washington University School of Medicine, St Louis, Missouri.
Kamlesh B Patel
Gary B Skolnick
Sybill D Naidoo
Matthew D Smyth
Albert S Woo
Washington University in St. Louis · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
SHORT-TERM TRAINING STUDENTS IN HEALTH PROFESSIONAL SCHOT35HL007815 · NHLBI · WASHINGTON UNIVERSITY · PI CHUNG, KOONG-NAH · 1995 to 2020
$2.8M
Pediatric Head Models for Improved Imaging of Neurological DevelopmentR43NS067726 · NINDS · ELECTRICAL GEODESICS, INC. · PI TUROVETS, SERGEI · 2010 to 2011
$695k
NCATS NIH HHS UL1 TR000448NHLBI NIH HHS T35 HL007815NINDS NIH HHS R43 NS067726NINDS NIH HHS R43-NS67726
6 · The paper itself

Abstract

backgroundThere have been conflicting reports on how sagittal synostosis affects cranial vault volume (CVV) and which surgical approach best normalizes skull volume. In this study, we compared CVV and cranial index (CI) of children with sagittal synostosis (before and after surgery) with those of control subjects. We also compared the effect of repair type on surgical outcome.

methodsComputed tomography scans of 32 children with sagittal synostosis and 61 age- and sex-matched control subjects were evaluated using previously validated segmentation software for CVV and CI. Sixteen cases underwent open surgery, and 16 underwent endoscopic surgery. Twenty-seven cases had both preoperative and postoperative scans.

resultsAge of subjects at computed tomography scan ranged from 1 to 9 months preoperatively and 15 to 25 months postoperatively. Mean age difference between cases and matched control subjects was 5 days. The mean CVV of cases preoperatively was nonsignificantly (17 mL) smaller than that of control subjects (P = 0.51). The mean CVV of postoperative children was nonsignificantly (24 mL) larger than that of control subjects (P = 0.51). Adjusting for age and sex, there was no significant difference in CVV between open and endoscopic cases postoperatively (β = 48 mL, P = 0.31). The mean CI increased 12% in both groups. There was no significant difference in mean postoperative CI (P = 0.18) between the 2 groups.

conclusionsPreoperatively, children with sagittal synostosis have no significant difference in CVV compared with control subjects. Type of surgery does not seem to affect CI and CVV 1 year postoperatively. Both open and endoscopic procedures result in CVVs similar to control subjects.

Indexed as

EndoscopyCraniosynostosesFemaleHumansImage Processing, Computer-AssistedInfantMaleOrgan SizePostoperative PeriodRegression AnalysisRetrospective StudiesSkullSoftware DesignTomography, X-Ray Computed

Identifiers

PMID25569396
PMCPMC4288482
OpenAlexW2317357730

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.