Evidence map›Paper›PMID 25569369›Full record

ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2015

Association between saccular function and gait speed: data from the Baltimore Longitudinal Study of Aging.

Andrew J Layman, Carol Li, Eleanor Simonsick, Luigi Ferrucci, John P Carey, Yuri Agrawal

Open access · greenAbstract read
In one paragraph

Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
7.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Risk factors affecting drop attack in patients with Meniere's disease.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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  8. Peripheral vestibular loss in noise-exposed firefighters.Frontiers in integrative neuroscience · 2023
    Article
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  13. [The relationship between vestibular function and gait parameters in vestibular dysfunctional patients with idiopathic sudden sensorineural hearing loss].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Andrew J Layman*Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore; and the †National Institute on Aging, Longitudinal Studies Section, Harbor Hospital, Baltimore, Maryland, U.S.A.
Carol Li
Eleanor Simonsick
Luigi Ferrucci
John P Carey
Yuri Agrawal
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

The Baltimore Longitudinal Study Of AgingZIAAG000015 · NIA · NATIONAL INSTITUTE ON AGING · PI SIMONSICK, ELEANOR MARIE · 2009 to 2025
$116.9M
Age-related Changes in the Vestibular System and Functional ImplicationsK23DC013056 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI AGRAWAL, YURI · 2014 to 2018
$1.2M
NIDCD NIH HHS K23 DC013056
6 · The paper itself

Abstract

objectiveTo investigate whether otolith function (saccular and utricular) is associated with walking performance. STUDY

designCross-sectional analysis of observational data collected in the Baltimore Longitudinal Study of Aging.

settingNational Institute on Aging Intramural Research Program Clinical Research Unit at Harbor Hospital, Baltimore, Maryland. PATIENTS: Community-dwelling participants. INTERVENTION(S): Cervical and ocular vestibular evoked myogenic potentials (VEMPs) were used to assess saccular and utricular function, respectively. MAIN OUTCOME MEASURE(S): Cervical and ocular VEMP latency and amplitude responses and usual, rapid, and narrow (20 cm) gait speed assessed over a 6-m course.

resultsIn 314 participants (mean age, 73.1 yr; range, 26-96 yr), cervical VEMP amplitude mediated the association between age and gait speed-particularly narrow walk speed-in both men and women. Cervical VEMP latency had an independent association with gait speed in age-, height-, and weight-adjusted analyses, although the direction of the association differed by sex. Greater cervical VEMP latency was associated with slower usual, rapid, and narrow gait speed in women but faster rapid gait speed in men. Neither the amplitude nor latency of ocular VEMP was associated with gait speed in men or women.

conclusionThese findings suggest that age-related slowing of gait speed is in part mediated by the decreased magnitude of saccular response associated with age. The sex-related differential association between saccular response latency and gait speed requires further study.

Indexed as

AdultAgedAged, 80 and overAgingBaltimoreBody WeightCross-Sectional StudiesFemaleGaitHumansLongitudinal StudiesMaleMiddle AgedSaccule and UtricleVestibular Evoked Myogenic PotentialsWalking

Identifiers

PMID25569369
PMCPMC4578664
OpenAlexW1970411341

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.