ArticlePLoS genetics2015
A re-examination of the selection of the sensory organ precursor of the bristle sensilla of Drosophila melanogaster.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Clustered cytoneme interactions contribute to peripheral nervous system patterning in Drosophila.bioRxiv : the preprint server for biology · 2026Article
- Neuralized-like proteins differentially activate Notch ligands.EMBO reports · 2025Article
- The Id protein Extramacrochaetae restrains the E protein Daughterless to regulate Notch, Rap1, and Sevenless within the R7 equivalence group of the Drosophila eye.Biology open · 2024Article
- Novel Genome-EngineeredGenes · 2024Article
- Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition.Developmental biology · 2024Article
- The meaning of ubiquitylation of the DSL ligand Delta for the development of Drosophila.BMC biology · 2023Article
- Myosin XV is a negative regulator of signaling filopodia during long-range lateral inhibition.bioRxiv : the preprint server for biology · 2023Article
- Cis-inhibition suppresses basal Notch signaling during sensory organ precursor selection.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genetic and Molecular Interactions betweenGenes · 2023Article
- Scabrous is distributed via signaling filopodia to modulate Notch response during bristle patterning in Drosophila.PloS one · 2023Article
- "A fly appeared": sable, a classic Drosophila mutation, maps to Yippee, a gene affecting body color, wings, and bristles.G3 (Bethesda, Md.) · 2022Article
- Lethal (2) giant discs (Lgd)/CC2D1 is required for the full activity of the ESCRT machinery.BMC biology · 2020Article
- Ordered patterning of the sensory system is susceptible to stochastic features of gene expression.eLife · 2020Article
- Review
- Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila.Nature communications · 2019Article
- Transcriptional and post-transcriptional regulation of extra macrochaetae during Drosophila adult peripheral neurogenesis.Developmental biology · 2019Article
- A role for actomyosin contractility in Notch signaling.BMC biology · 2019Article
- Lateral inhibition: Two modes of non-autonomous negative autoregulation by neuralized.PLoS genetics · 2018Article
- Regulation of theeLife · 2018Article
- Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases.Advances in experimental medicine and biology · 2018Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bristle sensillum of the imago of Drosophila is made of four cells that arise from a sensory organ precursor cell (SOP). This SOP is selected within proneural clusters (PNC) through a mechanism that involves Notch signalling. PNCs are defined through the expression domains of the proneural genes, whose activities enables cells to become SOPs. They encode tissue specific bHLH proteins that form functional heterodimers with the bHLH protein Daughterless (Da). In the prevailing lateral inhibition model for SOP selection, a transcriptional feedback loop that involves the Notch pathway amplifies small differences of proneural activity between cells of the PNC. As a result only one or two cells accumulate sufficient proneural activity to adopt the SOP fate. Most of the experiments that sustained the prevailing lateral inhibition model were performed a decade ago. We here re-examined the selection process using recently available reagents. Our data suggest a different picture of SOP selection. They indicate that a band-like region of proneural activity exists. In this proneural band the activity of the Notch pathway is required in combination with Emc to define the PNCs. We found a sub-group in the PNCs from which a pre-selected SOP arises. Our data indicate that most imaginal disc cells are able to adopt a proneural state from which they can progress to become SOPs. They further show that bristle formation can occur in the absence of the proneural genes if the function of emc is abolished. These results suggest that the tissue specific proneural proteins of Drosophila have a similar function as in the vertebrates, which is to determine the time of emergence and position of the SOP and to stabilise the proneural state.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.