ArticleNature communications2015
Co-infection alters population dynamics of infectious disease.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
105 citing papers in PubMed.
- Coinfections Dampen the Effects of Temperature on Host-Parasite Interactions.Ecology letters · 2026Article
- Higher Temperature and Host Age Alter Infection Outcomes in a Multi-Pathogen System.Ecology and evolution · 2026Article
- Co-infection with a viral pathogen (Theiler's murine encephalomyelitis virus) tended to improve host tolerance but significantly enhanced resistance to Heligmosomoides bakeri.Veterinary research communications · 2026Article
- Context-dependent indirect effects mediate ecological transitions between parasitism and mutualism.Communications biology · 2026Article
- Rapid adaptation accelerates competitive suppression in a parasite community.The ISME journal · 2026Article
- Molecular mechanisms of co-infections.EMBO reports · 2025Review
- On the Cause and Consequences of Coinfection: A General Mechanistic Framework of Within-Host Parasite Competition.Ecology letters · 2025Review
- Co-Infection, but Not Infection Intensity, Increases Shedding in a Gastrointestinal Helminth of Gamebirds.Ecology and evolution · 2025Article
- Co-Occurrence ofPlants (Basel, Switzerland) · 2025Article
- Respiratory infections in the post-COVID-19 era: impact, prevalence, and clinical characteristics of bacterial and viral co-infections.Frontiers in medicine · 2025Article
- Mathematical modelling and analysis for the co-infection of viral and bacterial diseases: a systematic review protocol.BMJ open · 2024Article
- Metabolic modelling as a powerful tool to identify critical components of Pneumocystis growth medium.PLoS computational biology · 2024Article
- Demographic and zoological drivers of infectome diversity in companion cats with ascites.mSystems · 2024Article
- Generalism in species interactions is more the consequence than the cause of ecological success.Nature ecology & evolution · 2024Article
- Coinfection accelerates transmission to new hosts despite no effects on virulence and parasite growth.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Interaction between Intestinal Parasites and the Gut Microbiota: Implications for the Intestinal Immune Response and Host Defence.Pathogens (Basel, Switzerland) · 2024Review
- Article
- Intensity and drivers of subtypes interference between seasonal influenza viruses in mainland China: A modeling study.iScience · 2024Article
- Bat white-nose disease fungus diversity in time and space.Biodiversity data journal · 2024Article
- Increased virulence due to multiple infection inParasitology · 2024Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Co-infections by multiple pathogen strains are common in the wild. Theory predicts co-infections to have major consequences for both within- and between-host disease dynamics, but data are currently scarce. Here, using common garden populations of Plantago lanceolata infected by two strains of the pathogen Podosphaera plantaginis, either singly or under co-infection, we find the highest disease prevalence in co-infected treatments both at the host genotype and population levels. A spore-trapping experiment demonstrates that co-infected hosts shed more transmission propagules than singly infected hosts, thereby explaining the observed change in epidemiological dynamics. Our experimental findings are confirmed in natural pathogen populations-more devastating epidemics were measured in populations with higher levels of co-infection. Jointly, our results confirm the predictions made by theoretical and experimental studies for the potential of co-infection to alter disease dynamics across a large host-pathogen metapopulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.