ArticleGenes and immunity
The higher frequency of IgA deficiency among Swedish twins is not explained by HLA haplotypes.
Article in Genes and immunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.Genome medicine · 2018Trial
- Total serum IgA levels and HLA-DQB1*02:01 allelic status.Immunologic research · 2024Article
- The Role of HLA in the Association between IgA Deficiency and Celiac Disease.Disease markers · 2021Review
- Article
- Innate Mechanisms in Selective IgA Deficiency.Frontiers in immunology · 2021Review
- The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency.Clinical reviews in allergy & immunology · 2020Review
- Risk factors of partial IgA deficiency among low serum IgA patients: a retrospective observational study.Central-European journal of immunology · 2020Article
- The clinical implications of selective IgA deficiency.Journal of translational autoimmunity · 2019Review
- Human IgM monoclonal antibodies block HIV-transmission to immune cells in cervico-vaginal tissues and across polarized epithelial cells in vitro.Scientific reports · 2018Article
- Identification of sequence variants influencing immunoglobulin levels.Nature genetics · 2017Article
- IgA1 Glycosylation Is Heritable in Healthy Twins.Journal of the American Society of Nephrology : JASN · 2017Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Serum immunoglobulin A (IgA) concentrations were determined in 12 600 adult Swedish twins, applying a high-throughput reverse-phase protein microarray technique. The prevalence of IgA deficiency (IgAD) was found to be 1:241 in monozygotic (MZ) twins and 1:198 in dizygotic (DZ) twins. Hence, the prevalence in twins is markedly elevated as compared with the normal Swedish adult population (1:600). The twins did not show a difference in the frequency of HLA haplotypes in comparison with almost 40 000 healthy Swedish controls. As expected, the risk-conveying HLA alleles A*01, B*08 and DRB1*01 were overrepresented among the IgAD twins and were also associated with significantly lower mean serum IgA concentrations in the twin cohort. In contrast, significantly higher mean IgA concentrations were found among individuals carrying the protective HLA alleles B*07 and DRB1*15. Exome sequencing data from two MZ twin pairs discordant for the deficiency showed no differences between the siblings. Model fitting analyses derived a heritability of 35% and indicate that genetic influences are modestly important for IgAD. The probandwise concordance rates for IgAD were found to be 31% for MZ and 13% for DZ twins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.