ArticlePLoS computational biology2015
150 years of the mass action law.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
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- Systems biology can provide guidance to synthetic biology in the pursuit of new drug targets.Frontiers in pharmacology · 2026Article
- Decomposable and Essentially Univariate Mass-Action Systems: Extensions of the Deficiency One Theorem.Journal of nonlinear science · 2026Article
- Reconstructing noisy gene regulation dynamics using extrinsic-noise-driven neural stochastic differential equations.PLoS computational biology · 2025Article
- An Asymptotic Analysis of Bivalent Monoclonal Antibody-Antigen Binding.Bulletin of mathematical biology · 2025Article
- The Dawn of High-Throughput and Genome-Scale Kinetic Modeling: Recent Advances and Future Directions.ACS synthetic biology · 2025Review
- Analysis of systemic effects of dioxin on human health through template-and-anchor modeling.PLoS computational biology · 2025Article
- Compartmental Models Driven by Renewal Processes: Survival Analysis and Applications to SVIS Epidemic Models.Scientific reports · 2025Article
- Review of the effect of atrazine on the HPG axes and steroidogenic pathways in males: relevance for testicular and prostate cancer.Frontiers in toxicology · 2025Review
- An open-source software for building and simulating ordinary differential equation models in biology.PloS one · 2025Article
- Optimal control of agent-based models via surrogate modeling.PLoS computational biology · 2025Article
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- Hamiltonian Computational Chemistry: Geometrical Structures in Chemical Dynamics and Kinetics.Entropy (Basel, Switzerland) · 2024Review
- A review of mathematical modeling of bone remodeling from a systems biology perspective.Frontiers in systems biology · 2024Article
- Systems Biology Approaches to Understanding COVID-19 Spread in the Population.Methods in molecular biology (Clifton, N.J.) · 2024Article
- A dynamic compartment model for xylem loading and long-distance transport of iron explains the effect of kanamycin on metal uptake inFrontiers in plant science · 2023Article
- Dominance analysis of competing protein assembly pathways.PloS one · 2023Article
- Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This year we celebrate the 150th anniversary of the law of mass action. This law is often assumed to have been "there" forever, but it has its own history, background, and a definite starting point. The law has had an impact on chemistry, biochemistry, biomathematics, and systems biology that is difficult to overestimate. It is easily recognized that it is the direct basis for computational enzyme kinetics, ecological systems models, and models for the spread of diseases. The article reviews the explicit and implicit role of the law of mass action in systems biology and reveals how the original, more general formulation of the law emerged one hundred years later ab initio as a very general, canonical representation of biological processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.