ArticlePLoS neglected tropical diseases2015
Low frequency of circulating CD8+ T stem cell memory cells in chronic chagasic patients with severe forms of the disease.
Article in PLoS neglected tropical diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Trial
- T cells responding to Trypanosoma cruzi detected by membrane TNF-α and CD154 in chagasic patients.Immunity, inflammation and disease · 2018Trial
- Functional, Antigen-Specific Stem Cell Memory (TFrontiers in immunology · 2018Trial
- Review
- T-cell exhaustion and stemness in antitumor immunity: Characteristics, mechanisms, and implications.Frontiers in immunology · 2023Review
- The frequency of CD4+ and CD8+ circulating T stem cell memory in type 1 diabetes.Immunity, inflammation and disease · 2022Article
- Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control.Immunity · 2022Article
- Review
- Stem-like T cells and niches: Implications in human health and disease.Frontiers in immunology · 2022Review
- Role of the Complement System in the Modulation of T-Cell Responses in Chronic Chagas Disease.Frontiers in cellular and infection microbiology · 2022Review
- High-dimensional mass cytometry identifies T cell and B cell signatures predicting reduced risk of Plasmodium vivax malaria.JCI insight · 2021Observational
- Immune exhaustion in chronic Chagas disease: Pro-inflammatory and immunomodulatory action of IL-27 in vitro.PLoS neglected tropical diseases · 2021Article
- CD8Frontiers in cellular and infection microbiology · 2021Article
- Differential Expression of Immune Response Genes in Asymptomatic Chronic Chagas Disease PatientsFrontiers in cellular and infection microbiology · 2021Article
- Memory T Cells in Transplantation: Old Challenges Define New Directions.Transplantation · 2020Review
- Clofazimine enhances the efficacy of BCG revaccination via stem cell-like memory T cells.PLoS pathogens · 2020Article
- Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.Nature communications · 2020Article
- CD40 Accelerates the Antigen-Specific Stem-Like Memory CD8Frontiers in immunology · 2020Article
- Understanding CD8Trends in parasitology · 2019Review
- Pathology and Pathogenesis of Chagas Heart Disease.Annual review of pathology · 2019Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCD8+ T cells have been shown to play a crucial role in Trypanosoma cruzi infection. Memory CD8+ T cells can be categorised based on their distinct differentiation stages and functional activities as follows: stem cell memory (TSCM), central memory (TCM), transitional memory (TTM), effector memory (TEM) and terminal effector (TTE) cells. Currently, the immune mechanisms that control T. cruzi in the chronic phase of the infection are unknown. METHODOLOGY/PRINCIPAL
findingsTo characterise the CD8+ T cell subsets that could be participating in the control of T. cruzi infection, in this study, we compared total and T. cruzi-specific circulating CD8+ T cells with distinctive phenotypic and functional features in chronic chagasic patients (CCPs) with different degrees of cardiac dysfunction. We observed a decreased frequency of total TSCM along with an increased frequency of TTE in CCPs with severe disease. Antigen-specific TSCM cells were not detectable in CCPs with severe forms of the disease. A functional profile of CD8+ T cell subsets among CCPs revealed a high frequency of monofunctional CD8+ T cells in the most severe patients with IFN-γ+- or TNF-α+-producing cells. CONCLUSIONS/SIGNIFICANCE: These findings suggest that CD8+ TSCM cells may be associated with the immune response to T. cruzi and outcome of Chagas disease, given that these cells may be involved in repopulating the T cell pool that controls infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.