Evidence map›Paper›PMID 25569027›Full record

ArticleOrganic letters2015

Synthesis of oxazocenones via gold(I)-catalyzed 8-endo-dig hydroalkoxylation of alkynamides.

Stephen S Scully, Shao-Liang Zheng, Bridget K Wagner, Stuart L Schreiber

Abstract read
In one paragraph

Article in Organic letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Stephen S ScullyCenter for the Science of Therapeutics, Broad Institute , 415 Main Street, Cambridge, Massachusetts 02142, United States.
Shao-Liang Zheng
Bridget K Wagner
Stuart L Schreiber

Funding

SYNTHESIS OF MATERIALS WITH PHYSIOLOGICAL PROPERTIESR01GM038627 · NIGMS · YALE UNIVERSITY · PI SCHREIBER, STUART L · 1987 to 2017
$10.5M
Small-molecule approaches to restore glycemic control in type 1 diabetesDP2DK083048 · NIDDK · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WAGNER, BRIDGET K · 2008 to 2010
$2.6M
SYNTHESIS OF MATERIALS WITH PHYSIOLOGICAL PROPERTIESR37GM038627 · NIGMS · HARVARD UNIVERSITY · PI SCHREIBER, STUART L · 1992 to 2001
$1.1M
Howard Hughes Medical InstituteNIDDK NIH HHS DP2 DK083048NIDDK NIH HHS DP2-DK083048NIGMS NIH HHS GM038627NIGMS NIH HHS R01 GM038627NIGMS NIH HHS R37 GM038627
6 · The paper itself

Abstract

Several benzoxazocenones have been found to exhibit novel cellular activities. In the present study, we report a gold(I)-catalyzed 8-endo-dig hydroalkoxylation reaction of alkynamides to access analogous oxazocenone scaffolds. This methodology provided an advanced intermediate, which was elaborated to a des-benzo analog of a bioactive benzoxazocenone.

Indexed as

AldehydesAlkynesAmidesCatalysisCyclizationGoldMolecular StructureOxazocinesStereoisomerismAldehydesAlkynesAmidesGoldOxazocines

Identifiers

PMID25569027
PMCPMC4323038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.