Trial reportAnnals of the American Thoracic Society2015
Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group.
Trial report in Annals of the American Thoracic Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Investigating the prognostic value of digital mobility outcomes in patients with chronic obstructive pulmonary disease: a systematic literature review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Self-management interventions for people with chronic obstructive pulmonary disease.The Cochrane database of systematic reviews · 2022Pooled it
- Interventions for promoting physical activity in people with chronic obstructive pulmonary disease (COPD).The Cochrane database of systematic reviews · 2020Pooled it
- Pooled it
- Home-based Physical Activity Coaching, Physical Activity, and Health Care Utilization in Chronic Obstructive Pulmonary Disease. Chronic Obstructive Pulmonary Disease Self-Management Activation Research Trial Secondary Outcomes.Annals of the American Thoracic Society · 2018Trial
- Promoting physical activity in COPD: Insights from a randomized trial of a web-based intervention and pedometer use.Respiratory medicine · 2017Trial
- Trial
- Trial
- Physical Activity Characteristics across GOLD Quadrants Depend on the Questionnaire Used.PloS one · 2016Trial
- Prevalence, awareness, treatment and control of chronic obstructive pulmonary disease (COPD) among community-dwelling adults aged 40 years and older in regional China.NPJ primary care respiratory medicine · 2026Article
- Addressing Low Physical Activity in Chronic Obstructive Pulmonary Disease: The Importance of Patients' Symptom Perception.Tuberculosis and respiratory diseases · 2026Article
- Are Real-World Mobility Patterns Early Indicators of COPD Onset? Insights from Wrist-Worn Sensors.International journal of chronic obstructive pulmonary disease · 2026Article
- Decreased 6-minute walk distance after pulmonary resection increases the risk of postoperative hospital re-admission: a retrospective cohort study.BMC cancer · 2025Article
- Prevalence and prognostic importance of exercise limitation and physical inactivity in COPD.Breathe (Sheffield, England) · 2024Review
- Six-Minute Walking Test and 30 Seconds Chair-Stand-Test as Predictors of Mortality in COPD - A Cohort Study.International journal of chronic obstructive pulmonary disease · 2022Article
- Radiofrequency therapy improves exercise capacity of mice with emphysema.Scientific reports · 2021Article
- Variability in Hourly Activity Levels: Statistical Noise or Insight Into Older Adult Frailty?The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Clinical impact of forced vital capacity on exercise performance in patients with chronic obstructive pulmonary disease.Journal of thoracic disease · 2021Article
- The 6-Minute Walk Test predicts long-term physical improvement among intensive care unit survivors: a prospective cohort study.Revista Brasileira de terapia intensiva · 2021Article
- Effect of an unsupervised walking program on tolerance to exercise in patients with chronic obstructive pulmonary disease.Journal of thoracic disease · 2020Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
rationaleThe 2011 combined Global Initiative for Chronic Obstructive Lung Disease (GOLD) assessment incorporates symptoms, exacerbation history, and spirometry in discriminating risk of exacerbations in patients with chronic obstructive pulmonary disease (COPD). Six-minute-walk distance (6MWD) and accelerometry also have been used to assess disease severity in COPD. The association between these measures and the risks of hospitalization and mortality in the context of GOLD 2011 is unknown.
objectivesTo describe changes in exercise tolerance and physical activity over time in patients with COPD and to test the hypothesis that lower baseline 6MWD or accelerometry step count is associated with increased risk of COPD-related hospitalization or all-cause mortality, independent of GOLD 2011 group.
methodsPhysical function and medical outcomes were prospectively assessed in 326 patients with moderate to severe COPD in INSPIRE-II, a randomized controlled trial of a coping skills training intervention. Cox models were used to determine if GOLD 2011 group, 6MWD, or accelerometry steps were associated with risk of COPD-related hospitalization or all-cause mortality. MEASUREMENTS AND MAIN
resultsPhysical function declined over time in GOLD group D but remained stable in groups A, B, and C. GOLD classification was associated with time to death or first COPD-related hospitalization. Baseline 6MWD was more strongly associated with time to death or first COPD-related hospitalization (hazard ratio, 0.50 [95% confidence interval, 0.34, 0.73] per 150 m, P=0.0003) than GOLD 2011 classification. A similar relationship was observed for accelerometry steps (hazard ratio, 0.80 [95% confidence interval, 0.70, 0.92] per 1,000 steps, P=0.002).
conclusionsExercise tolerance and daily physical activity are important predictors of hospitalization and mortality in COPD, independent of GOLD 2011 classification. Physical function may represent a modifiable risk factor that warrants increased attention as a target for interventions to improve clinically meaningful outcomes in COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.