ReviewClinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases2014
Hepatic osteodystrophy.
Review in Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Association between primary biliary cholangitis and osteoporosis: meta-analysis.Clinical rheumatology · 2017Pooled it
- Safety and efficacy of risedronate for patients with esophageal varices and liver cirrhosis: a non-randomized clinical trial.Scientific reports · 2019Trial
- Effects of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D Concentrations in Cirrhotic Patients: A Randomized Controlled Trial.Nutrients · 2016Trial
- Association between osteoporosis and waitlist mortality in liver transplant candidates.Scientific reports · 2026Article
- Screening of genes co-associated with osteoporosis and chronic HBV infection based on bioinformatics analysis and machine learning.Frontiers in immunology · 2024Article
- Osteochondral lesions in Wilson's disease: case report and literature review.AME case reports · 2024Article
- Trace Element Imbalances in Acquired Hepatocerebral Degeneration and Changes after Liver Transplant.Biology · 2023Article
- Review
- Primary biliary cirrhosis and osteoporosis: a bidirectional two-sample Mendelian randomization study.Frontiers in immunology · 2023Article
- Hepatic osteodystrophy with hypophosphataemia and elevated fibroblast growth factor-23.Journal of paediatrics and child health · 2022Article
- A Systematic Review and Meta-Analysis on Metabolic Bone Disease in Patients with Primary Sclerosing Cholangitis.Journal of clinical medicine · 2022Review
- Article
- Short-Term Outcomes of Total Hip Arthroplasty after Liver Transplantation.Arthroplasty today · 2021Article
- Article
- Organ-organ communication: The liver's perspective.Theranostics · 2021Review
- Prevalence and characteristics of bone disease in cirrhotic patients.Hepatology forum · 2020Article
- Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease.Journal of clinical and translational hepatology · 2018Article
- A study on OPG/RANK/RANKL axis in osteoporotic bile duct-ligated rats and the involvement of nitrergic and opioidergic systems.Research in pharmaceutical sciences · 2018Article
- Adefovir dipivoxil induced hypophosphatemic osteomalacia in chronic hepatitis B: a comparative study of Chinese and foreign case series.BMC pharmacology & toxicology · 2018Article
- Risk factors for osteoporosis in liver cirrhosis patients measured by transient elastography.Medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic disturbances of bone are frequent in patients with chronic liver disease. The prevalence of osteoporosis among patients with advanced chronic liver disease is reported between 12% and 55%; it is higher in primary biliary cirrhosis. All patients with advanced liver disease should be screened for osteoporosis with a densitometry, especially if the etiology is cholestatic and in the presence of other risk factors. Clinical relevance of hepatic osteodystrophy increases after liver transplantation. After liver transplant, a rapid loss of bone mineral density can be detected in the first 6 months, followed by stabilization and slight improvement of the values. At the time of transplantation, bone density values are very important prognostic factors. Therapy of hepatic osteodystrophy is based primarily on the control of risk factors: cessation of tobacco and alcohol assumption, reduction of caffeine ingestion, exercise, supplementation of calcium and vitamin D, limitation of drugs such as loop diuretics, corticosteroids, cholestyramine. Bisphosphonates have been proposed for the therapy of osteoporosis in patients with liver disease, particularly after liver transplantation. The possible side effects of oral administration of bisphosphonates, such as the occurrence of esophageal ulcerations, are of particular concern in patients with liver cirrhosis and portal hypertension, due to the risk of gastrointestinal hemorrhage from ruptured esophageal varices, although this risk is probably overestimated.
Indexed as
Identifiers
25568651PMC4269141W4236479130What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.