ArticleThe international journal of neuropsychopharmacology2015
Regional differences in brain-derived neurotrophic factor levels and dendritic spine density confer resilience to inescapable stress.
Article in The international journal of neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 103 citations in OpenAlex.
- Sex differences in resilience at puberty depend upon divergent effects of a stress steroid at α4βδ GABABrain research · 2025Article
- Phytochemicals Targeting BDNF Signaling for Treating Neurological Disorders.Brain sciences · 2025Review
- Insights for the Next Generation of Ketamine for the Treatment of Depressive Disorder.Journal of medicinal chemistry · 2025Review
- Influence of gut microbiota on resilience and its possible mechanisms.International journal of biological sciences · 2023Review
- Aberrant ventral dentate gyrus structure and function in trauma susceptible mice.Translational psychiatry · 2022Article
- Running from Stress: Neurobiological Mechanisms of Exercise-Induced Stress Resilience.International journal of molecular sciences · 2022Review
- Post-weaning social isolation causes sex-specific alterations to dendritic spine density in subregions of the prefrontal cortex and nucleus accumbens of adult mice.Brain research · 2022Article
- The Regulation of Glutamate Transporter 1 in the Rapid Antidepressant-Like Effect of Ketamine in Mice.Frontiers in behavioral neuroscience · 2022Article
- Analysis of Antidepressant-like Effects and Action Mechanisms of GSB-106, a Small Molecule, Affecting the TrkB Signaling.International journal of molecular sciences · 2021Article
- Subjective arousal and perceived control clarify heterogeneity in inflammatory and affective outcomes.Brain, behavior, & immunity - health · 2021Article
- Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer's Disease.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2021Review
- Rapid-acting and long-lasting antidepressant-like action of (R)-ketamine in Nrf2 knock-out mice: a role of TrkB signaling.European archives of psychiatry and clinical neuroscience · 2021Article
- Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents.Translational psychiatry · 2021Article
- Requirements of Postnatal proBDNF in the Hippocampus for Spatial Memory Consolidation and Neural Function.Frontiers in cell and developmental biology · 2021Article
- Severe childhood and adulthood stress associates with neocortical layer-specific reductions of mature spines in psychiatric disorders.Neurobiology of stress · 2020Article
- The alterations of glutamate transporter 1 and glutamine synthetase in the rat brain of a learned helplessness model of depression.Psychopharmacology · 2020Article
- Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury.European archives of psychiatry and clinical neuroscience · 2020Article
- The molecular and cellular mechanisms of depression: a focus on reward circuitry.Molecular psychiatry · 2019Review
- A potential role for microglia in stress- and drug-induced plasticity in the nucleus accumbens: A mechanism for stress-induced vulnerability to substance use disorder.Neuroscience and biobehavioral reviews · 2019Review
- Modelling resilience in adolescence and adversity: a novel framework to inform research and practice.Translational psychiatry · 2019Review
Corrections and comments
- Erratum issued
- Retracted
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the learned helplessness (LH) paradigm, approximately 35% of rats are resilient to inescapable stress.
methodsThe roles of brain-derived neurotrophic factor (BDNF) and dendritic spine density in the brain regions of LH (susceptible) and non-LH rats (resilient) were examined. Western blot analysis and Golgi staining were performed.
resultsBDNF levels in the medial prefrontal cortex, CA3, and dentate gyrus (DG) were significantly lower in the LH group than in the control and non-LH groups, whereas BDNF levels in the nucleus accumbens (NAc) in the LH group but not the non-LH group were significantly higher than those in the control group. Furthermore, spine density in the prelimbic cortex, CA3, and DG was significantly lower in the LH group than in the control and non-LH groups, although spine density in the NAc was significantly higher in the LH group than in the control and non-LH groups.
conclusionsThe results suggest that regional differences in BDNF levels and spine density in rat brain may contribute to resilience to inescapable stress.
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