Evidence map›Paper›PMID 25568216›Full record

SynthesisClinical journal of the American Society of Nephrology : CJASN2015

A systematic review of glomerular hyperfiltration assessment and definition in the medical literature.

Francois Cachat, Christophe Combescure, Michel Cauderay, Eric Girardin, Hassib Chehade

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical journal of the American Society of Nephrology : CJASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03629561 (Diagnosis of Monoclonal Gammopathy of Renal Significance in Patients With Paraproteinemias), which is not on this map. Cited by 94 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03629561 unknown statusnot on this mapstarted 2019, after this paper: background citation

Diagnosis of Monoclonal Gammopathy of Renal Significance in Patients With Paraproteinemias

Typeobservational_patient_registrySponsorAcademia Nacional de MedicinaRan2019 to 2021Enrolled15ConditionsMonoclonal Gammopathy of Renal Significance
3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. A systematic review of glomerular hyperfiltration assessment and definition in the medical literature.Clinical journal of the American Society of Nephrology : CJASN · 2015
    Pooled it
  3. Review
  4. Article
  5. Article
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  7. Article
  8. Article
  9. Kidney consequences of obesity.Pediatric nephrology (Berlin, Germany) · 2025
    Review
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francois CachatDepartment of Pediatrics, Division of Pediatric Nephrology, University Hospital, Lausanne, Switzerland; francois.cachat@chuv.ch.
Christophe CombescureCRC and Division of Clinical Epidemiology, Department of Health and Community Medicine, University of Geneva University Hospitals of Geneva, Geneva, Switzerland;
Michel CauderayDepartment of Pediatrics, Pediatric Endocrinology Unit, Samaritain Regional Hospital, Vevey, Switzerland; and.
Eric GirardinDepartment of Pediatrics, Division of Pediatric Nephrology, University Hospital, Geneva, Switzerland.
Hassib ChehadeDepartment of Pediatrics, Division of Pediatric Nephrology, University Hospital, Lausanne, Switzerland;

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesEvaluation of glomerular hyperfiltration (GH) is difficult; the variable reported definitions impede comparisons between studies. A clear and universal definition of GH would help in comparing results of trials aimed at reducing GH. This study assessed how GH is measured and defined in the literature. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Three databases (Embase, MEDLINE, CINAHL) were systematically searched using the terms "hyperfiltration" or "glomerular hyperfiltration". All studies reporting a GH threshold or studying the effect of a high GFR in a continuous manner against another outcome of interest were included.

resultsThe literature search was performed from November 2012 to February 2013 and updated in August 2014. From 2013 retrieved studies, 405 studies were included. Threshold use to define GH was reported in 55.6% of studies. Of these, 88.4% used a single threshold and 11.6% used numerous thresholds adapted to participant sex or age. In 29.8% of the studies, the choice of a GH threshold was not based on a control group or literature references. After 2004, the use of GH threshold use increased (P<0.001), but the use of a control group to precisely define that GH threshold decreased significantly (P<0.001); the threshold did not differ among pediatric, adult, or mixed-age studies. The GH threshold ranged from 90.7 to 175 ml/min per 1.73 m(2) (median, 135 ml/min per 1.73 m(2)).

conclusionThirty percent of studies did not justify the choice of threshold values. The decrease of GFR in the elderly was rarely considered in defining GH. From a methodologic point of view, an age- and sex-matched control group should be used to define a GH threshold.

Indexed as

Terminology as TopicGlomerular Filtration RateHumansKidney GlomerulusReference ValuesRenal Insufficiency, Chroniccreatinine clearancediabetic nephropathyglomerular hyperfiltrationhemodynamics and vascular regulationhyperfiltration

Identifiers

PMID25568216
PMCPMC4348676

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.