ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
cJun and CREB2 in the postsynaptic neuron contribute to persistent long-term facilitation at a behaviorally relevant synapse.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 30 citations in OpenAlex.
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- AP-1 controls the p11-dependent antidepressant response.Molecular psychiatry · 2020Article
- Postsynaptic effects ofLearning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Role of p90 ribosomal S6 kinase in long-term synaptic facilitation and enhanced neuronal excitability.Scientific reports · 2020Article
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Autocrine signaling by anProceedings of the National Academy of Sciences of the United States of America · 2018Article
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- Activating Transcription Factor 4 (ATF4) Regulates Neuronal Activity by Controlling GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- A CREB2-targeting microRNA is required for long-term memory after single-trial learning.Scientific reports · 2018Article
- Molecular correlates of separate components of training that contribute to long-term memory formation after learning that food is inedible inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction ofFrontiers in molecular neuroscience · 2018Article
- Transcriptional correlates of memory maintenance following long-term sensitization ofLearning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Characterization and reversal of Doxorubicin-mediated biphasic activation of ERK and persistent excitability in sensory neurons of Aplysia californica.Scientific reports · 2017Article
- Cell-Specific PKM Isoforms Contribute to the Maintenance of Different Forms of Persistent Long-Term Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Role of protein synthesis and DNA methylation in the consolidation and maintenance of long-term memory ineLife · 2017Article
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4 authors at 2 institutions in 1 country.
Funding
Abstract
Basic region leucine zipper (bZIP) transcription factors regulate gene expression critical for long-term synaptic plasticity or neuronal excitability contributing to learning and memory. At sensorimotor synapses of Aplysia, changes in activation or expression of CREB1 and CREB2 in sensory neurons are required for long-term synaptic plasticity. However, it is unknown whether concomitant stimulus-induced changes in expression and activation of bZIP transcription factors in the postsynaptic motor neuron also contribute to persistent long-term facilitation (P-LTF). We overexpressed various forms of CREB1, CREB2, or cJun in the postsynaptic motor neuron L7 in cell culture to examine whether these factors contribute to P-LTF. P-LTF is evoked by 2 consecutive days of 5-HT applications (2 5-HT), while a transient form of LTF is produced by 1 day of 5-HT applications (1 5-HT). Significant increases in the expression of both cJun and CREB2 mRNA in L7 accompany P-LTF. Overexpressing each bZIP factor in L7 did not alter basal synapse strength, while coexpressing cJun and CREB2 in L7 evoked persistent increases in basal synapse strength. In contrast, overexpressing cJun and CREB2 in sensory neurons evoked persistent decreases in basal synapse strength. Overexpressing wild-type cJun or CREB2, but not CREB1, in L7 can replace the second day of 5-HT applications in producing P-LTF. Reducing cJun activity in L7 blocked P-LTF evoked by 2 5-HT. These results suggest that expression and activation of different bZIP factors in both presynaptic and postsynaptic neurons contribute to persistent change in synapse strength including stimulus-dependent long-term synaptic plasticity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.