ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Learning modifies odor mixture processing to improve detection of relevant components.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- Data-Constrained Recurrent Network Neural Model Uncovers the Circuit Mechanism of Olfactory OFF Responses.bioRxiv : the preprint server for biology · 2026Article
- Article
- Manifold learning for olfactory habituation to strongly fluctuating backgrounds.bioRxiv : the preprint server for biology · 2025Article
- Plasticity in inhibitory networks improves pattern separation in early olfactory processing.Communications biology · 2025Article
- Reinforcement expectation in the honeybee (Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Gain modulation and odor concentration invariance in early olfactory networks.PLoS computational biology · 2023Article
- Biological constraints on configural odour mixture perception.The Journal of experimental biology · 2022Article
- Article
- Learning-dependent plasticity in the antennal lobe improves discrimination and recognition of odors in the honeybee.Cell and tissue research · 2021Review
- Olfactory coding in honeybees.Cell and tissue research · 2021Review
- Habituation as a neural algorithm for online odor discrimination.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Experience-dependent tuning of early olfactory processing in the adult honey bee,The Journal of experimental biology · 2020Article
- Odor mixture training enhances dogs' olfactory detection of Home-Made Explosive precursors.Heliyon · 2018Article
- Odorant mixtures elicit less variable and faster responses than pure odorants.PLoS computational biology · 2018Article
- Differential effects of adaptation on odor discrimination.Journal of neurophysiology · 2018Article
- Learning-Dependent and -Independent Enhancement of Mitral/Tufted Cell Glomerular Odor Responses Following Olfactory Fear Conditioning in Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Comparative study of chemical neuroanatomy of the olfactory neuropil in mouse, honey bee, and human.Biological cybernetics · 2018Article
- Morphofunctional experience-dependent plasticity in the honeybee brain.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Experience during early adulthood shapes the learning capacities and the number of synaptic boutons in the mushroom bodies of honey bees (Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Olfactory learning without the mushroom bodies: Spiking neural network models of the honeybee lateral antennal lobe tract reveal its capacities in odour memory tasks of varied complexities.PLoS computational biology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Honey bees have a rich repertoire of olfactory learning behaviors, and they therefore are an excellent model to study plasticity in olfactory circuits. Recent behavioral, physiological, and molecular evidence suggested that the antennal lobe, the first relay of the olfactory system in insects and analog to the olfactory bulb in vertebrates, is involved in associative and nonassociative olfactory learning. Here we use calcium imaging to reveal how responses across antennal lobe projection neurons change after association of an input odor with appetitive reinforcement. After appetitive conditioning to 1-hexanol, the representation of an odor mixture containing 1-hexanol becomes more similar to this odor and less similar to the background odor acetophenone. We then apply computational modeling to investigate how changes in synaptic connectivity can account for the observed plasticity. Our study suggests that experience-dependent modulation of inhibitory interactions in the antennal lobe aids perception of salient odor components mixed with behaviorally irrelevant background odors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.