ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Methylphenidate Inhibits the Development of Myopia by Altering Dopamine and Norepinephrine Reuptake.Investigative ophthalmology & visual science · 2025Article
- Neurexin1α knockout in rats causes aberrant social behaviour: relevance for autism and schizophrenia.Psychopharmacology · 2025Article
- Noradrenergic modulation of play in Sprague-Dawley and F344 rats.Psychopharmacology · 2025Article
- Nuancing 'Emotional' Social Play: Does Play Behaviour Always Underlie a Positive Emotional State?Animals : an open access journal from MDPI · 2024Review
- Play partner preferences among groups of unfamiliar juvenile male rats.Scientific reports · 2024Article
- Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats.Pharmacological reports : PR · 2024Article
- Trait sensitivity to positive feedback is a predisposing factor for several aspects of compulsive alcohol drinking in male rats: behavioural, physiological, and molecular correlates.Psychopharmacology · 2024Article
- Psychostimulants and social behaviors.Frontiers in pharmacology · 2024Review
- Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats.Neuroscience and biobehavioral reviews · 2023Review
- Prefrontal modulation of anxiety through a lens of noradrenergic signaling.Frontiers in systems neuroscience · 2023Review
- Role of environmental enrichment on social interaction, anxiety, locomotion, and memory in Wistar rats under chronic methylphenidate intake.Frontiers in behavioral neuroscience · 2023Article
- 1MeTIQ and olanzapine, despite their neurochemical impact, did not ameliorate performance in fear conditioning and social interaction tests in an MK-801 rat model of schizophrenia.Pharmacological reports : PR · 2021Article
- Evidence of Altered Habenular Intrinsic Functional Connectivity in Pediatric ADHD.Journal of attention disorders · 2021Article
- The Effects of Drugs on Behavior Maintained by Social Contact: Role of Monoamines in Social Reinforcement.Frontiers in behavioral neuroscience · 2021Article
- Detrimental effects of the 'bath salt' methylenedioxypyrovalerone on social play behavior in male rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Methamphetamine exposure during the first, but not the second half of prenatal development, affects social play behavior.Physiological research · 2020Article
- From adolescence to late aging: A comprehensive review of social behavior, alcohol, and neuroinflammation across the lifespan.International review of neurobiology · 2019Review
- Subjecting Dams to Early Life Stress and Perinatal Fluoxetine Treatment Differentially Alters Social Behavior in Young and Adult Rat Offspring.Frontiers in neuroscience · 2019Article
- Chronic oral methylphenidate treatment increases microglial activation in rats.Journal of neural transmission (Vienna, Austria : 1996) · 2018Article
- Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Positive social interactions during the juvenile and adolescent phases of life, in the form of social play behavior, are important for social and cognitive development. However, the neural mechanisms of social play behavior remain incompletely understood. We have previously shown that methylphenidate and atomoxetine, drugs widely used for the treatment of attention-deficit hyperactivity disorder (ADHD), suppress social play in rats through a noradrenergic mechanism of action. Here, we aimed to identify the neural substrates of the play-suppressant effects of these drugs. Methylphenidate is thought to exert its effects on cognition and emotion through limbic corticostriatal systems. Therefore, methylphenidate was infused into prefrontal and orbitofrontal cortical regions as well as into several subcortical limbic areas implicated in social play. Infusion of methylphenidate into the anterior cingulate cortex, infralimbic cortex, basolateral amygdala, and habenula inhibited social play, but not social exploratory behavior or locomotor activity. Consistent with a noradrenergic mechanism of action of methylphenidate, infusion of the noradrenaline reuptake inhibitor atomoxetine into these same regions also reduced social play. Methylphenidate administration into the prelimbic, medial/ventral orbitofrontal, and ventrolateral orbitofrontal cortex, mediodorsal thalamus, or nucleus accumbens shell was ineffective. Our data show that the inhibitory effects of methylphenidate and atomoxetine on social play are mediated through a distributed network of prefrontal and limbic subcortical regions implicated in cognitive control and emotional processes. These findings increase our understanding of the neural underpinnings of this developmentally important social behavior, as well as the mechanism of action of two widely used treatments for ADHD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.