ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Age-related changes in synapse ultrastructure and neuroprotective effect of dietary curcumin in the lateral prefrontal cortex layer 3 of the rhesus monkey.GeroScience · 2026Article
- Alternative splicing in layer 3 pyramidal neurons differs across regions of the human cortical hierarchy.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Intrinsic neuronal diversity as a substrate for cortical area specialization in primate vision.Nature communications · 2026Article
- Transcriptional and functional profiles of muscarinic receptor-expressing neurons in primate lateral prefrontal and anterior cingulate cortices.Communications biology · 2026Article
- High-frequency bursts facilitate fast communication for human spatial attention.Nature neuroscience · 2026Article
- Specializations in Amygdalar and Hippocampal Innervation of the Primate Nucleus Accumbens Shell.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Stress and Inflammation Target Dorsolateral Prefrontal Cortex Function: Neural Mechanisms Underlying Weakened Cognitive Control.Biological psychiatry · 2025Review
- Synaptic alterations in pyramidal cells following genetic manipulation of neuronal excitability in monkey prefrontal cortex.Journal of neurophysiology · 2025Article
- Reduction of inflammatory biomarkers underlies extracellular vesicle mediated functional recovery in an aged monkey model of cortical injury.Frontiers in aging neuroscience · 2025Article
- Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17.Brain structure & function · 2024Article
- The meso-connectomes of mouse, marmoset, and macaque: network organization and the emergence of higher cognition.Cerebral cortex (New York, N.Y. : 1991) · 2024Review
- Immune proteins C1q and CD47 may contribute to aberrant microglia-mediated synapse loss in the aging monkey brain that is associated with cognitive impairment.GeroScience · 2024Article
- Unambiguous identification of asymmetric and symmetric synapses using volume electron microscopy.Frontiers in neuroanatomy · 2024Article
- Information encoded in volumes and areas of dendritic spines is nearly maximal across mammalian brains.Scientific reports · 2023Article
- Article
- Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys.Journal of neuroinflammation · 2023Article
- Strength of Excitatory Inputs to Layer 3 Pyramidal Neurons During Synaptic Pruning in the Monkey Prefrontal Cortex: Relevance for the Pathogenesis of Schizophrenia.Biological psychiatry · 2023Article
- Mechanisms regulating the properties of inhibition-based gamma oscillations in primate prefrontal and parietal cortices.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Mesenchymal-Derived Extracellular Vesicles Enhance Microglia-mediated Synapse Remodeling after Cortical Injury in Rhesus Monkeys.Research square · 2023Article
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2 authors.
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Abstract
Understanding commonalities and differences in glutamatergic synaptic signaling is essential for understanding cortical functional diversity, especially in the highly complex primate brain. Previously, we have shown that spontaneous EPSCs differed markedly in layer 3 pyramidal neurons of two specialized cortical areas in the rhesus monkey, the high-order lateral prefrontal cortex (LPFC) and the primary visual cortex (V1). Here, we used patch-clamp recordings and confocal and electron microscopy to determine whether these distinct synaptic responses are due to differences in firing rates of presynaptic neurons and/or in the features of presynaptic or postsynaptic entities. As with spontaneous EPSCs, TTX-insensitive (action potential-independent) miniature EPSCs exhibited significantly higher frequency, greater amplitude, and slower kinetics in LPFC compared with V1 neurons. Consistent with these physiological differences, LPFC neurons possessed higher densities of spines, and the mean width of large spines was greater compared with those on V1 neurons. Axospinous synapses in layers 2-3 of LPFC had larger postsynaptic density surface areas and a higher proportion of large perforated synapses compared with V1. Axonal boutons in LPFC were also larger in volume and contained ∼ 1.6× more vesicles than did those in V1. Further, LPFC had a higher density of AMPA GluR2 receptor labeling than V1. The properties of spines and synaptic currents of individual layer 3 pyramidal neurons measured here were significantly correlated, consistent with the idea that significantly more frequent and larger synaptic currents are likely due to more numerous, larger, and more powerful synapses in LPFC compared with V1.
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