ArticleEvolutionary applications2011
Ten questions for evolutionary studies of disease vulnerability.
Article in Evolutionary applications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Combination of 247 Genome-Wide Association Studies Reveals High Cancer Risk as a Result of Evolutionary Adaptation.Molecular biology and evolution · 2018Pooled it
- No genome-wide correlations and little shared genetic architecture between reproductive life-history traits and estrogen receptor-positive breast cancer risk.Molecular biology and evolution · 2026Article
- Highly Cited Articles in Evolutionary Psychiatry: Assessment With a Quality and Error Rating Scale.Alpha psychiatry · 2025Article
- The impact of altered dietary adenine concentrations on the gut microbiota inFrontiers in microbiology · 2024Article
- Evolutionary psychiatry: foundations, progress and challenges.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Integrating evolutionary, developmental and physiological mismatch.Evolution, medicine, and public health · 2023Review
- Genetic etiology and clinical challenges of phenylketonuria.Human genomics · 2022Review
- Integrating Evolutionary, Cultural, and Computational Psychiatry: A Multilevel Systemic Approach.Frontiers in psychiatry · 2022Article
- Reinterpreting patterns of variation in human thyroid function: An evolutionary ecology perspective.Evolution, medicine, and public health · 2021Review
- Race and genetics versus 'race' in genetics: A systematic review of the use of African ancestry in genetic studies.Evolution, medicine, and public health · 2021Review
- Quantifying simultaneous innovations in evolutionary medicine.Theory in biosciences = Theorie in den Biowissenschaften · 2020Article
- Evolutionary and developmental mismatches are consequences of adaptive developmental plasticity in humans and have implications for later disease risk.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- The Genetic Variability ofGenes · 2019Review
- The status of evolutionary medicine education in North American medical schools.BMC medical education · 2015Article
- Toward a Deeper Understanding of the Genetics of Bipolar Disorder.Frontiers in psychiatry · 2015Review
- Long-distance gene flow outweighs a century of local selection and prevents local adaptation in the Irish famine pathogen Phytophthora infestans.Evolutionary applications · 2014Article
- Androgen receptor polyglutamine repeat number: models of selection and disease susceptibility.Evolutionary applications · 2013Article
- Evolution and medicine in undergraduate education: a prescription for all biology students.Evolution; international journal of organic evolution · 2012Article
- Nothing in medicine makes sense, except in the light of evolution.Journal of molecular medicine (Berlin, Germany) · 2012Review
- Evolutionary molecular medicine.Journal of molecular medicine (Berlin, Germany) · 2012Review
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many evolutionary applications in medicine rely on well-established methods, such as population genetics, phylogenetic analysis, and observing pathogen evolution. Approaches to evolutionary questions about traits that leave bodies vulnerable to disease are less well developed. Strategies for formulating questions and hypotheses remain unsettled, and methods for testing evolutionary hypotheses are unfamiliar to many in medicine. This article uses recent examples to illustrate successful strategies and some common challenges. Ten questions arise in the course of considering hypotheses about traits that leave bodies vulnerable to disease. Addressing them systematically can help minimize confusion and errors.
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Registered trials
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