ArticleEvolutionary applications2009
Why do adaptive immune responses cross-react?
Article in Evolutionary applications, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases.Journal of translational autoimmunity · 2025Review
- Investigating the association between yellow fever vaccination and symptomatic acute Zika virus infection: a case-control study.Revista da Sociedade Brasileira de Medicina Tropical · 2025Article
- Aetiologies of bacterial tick-borne febrile illnesses in humans in Africa: diagnostic limitations and the need for improvement.Frontiers in medicine · 2024Review
- Bet-hedging in innate and adaptive immune systems.Evolution, medicine, and public health · 2022Article
- Yellow fever vaccine protects mice against Zika virus infection.PLoS neglected tropical diseases · 2021Article
- Review
- Efficient Plant Production of Recombinant NS1 Protein for Diagnosis of Dengue.Frontiers in plant science · 2020Article
- Distribution and prevalence of vector-borne diseases in California chipmunks (Tamias spp.).PloS one · 2017Article
- Cross-Immunity and Community Structure of a Multiple-Strain Pathogen in the Tick Vector.Applied and environmental microbiology · 2015Article
- Multivariate immune defences and fitness in the wild: complex but ecologically important associations among plasma antibodies, health and survival.Proceedings. Biological sciences · 2014Article
- Does homologous reinfection drive multiple-wave influenza outbreaks? Accounting for immunodynamics in epidemiological models.Epidemics · 2013Article
- Explaining rapid reinfections in multiple-wave influenza outbreaks: Tristan da Cunha 1971 epidemic as a case study.Proceedings. Biological sciences · 2011Article
- Consequences of host heterogeneity, epitope immunodominance, and immune breadth for strain competition.Journal of theoretical biology · 2011Article
- Editorial: 2009 in review.Evolutionary applications · 2010Article
- Antibody isotype analysis of malaria-nematode co-infection: problems and solutions associated with cross-reactivity.BMC immunology · 2010Article
- Editorial: evolutionary medicine special issue.Evolutionary applications · 2009Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Antigen specificity of adaptive immune responses is often in the host's best interests, but with important and as yet unpredictable exceptions. For example, antibodies that bind to multiple flaviviral or malarial species can provide hosts with simultaneous protection against many parasite genotypes. Vaccinology often aims to harness such imprecision, because cross-reactive antibodies might provide broad-spectrum protection in the face of antigenic variation by parasites. However, the causes of cross-reactivity among immune responses are not always known, and here, we explore potential proximate and evolutionary explanations for cross-reactivity. We particularly consider whether cross-reactivity is the result of constraints on the ability of the immune system to process information about the world of antigens, or whether an intermediate level of cross-reactivity may instead represent an evolutionary optimum. We conclude with a series of open questions for future interdisciplinary research, including the suggestion that the evolutionary ecology of information processing might benefit from close examination of immunological data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.