Evidence map›Paper›PMID 25567825›Full record

ArticleJournal of the American Board of Family Medicine : JABFM

Comparable sustained virologic suppression between community- and academic-based HIV care settings.

Carolyn Chu, Moonseong Heo, Alex Peshansky, Galina Umanski, Paul Meissner, Cindy Voss, Peter A Selwyn

Abstract readComparative StudyMulticenter Study
In one paragraph

Article in Journal of the American Board of Family Medicine : JABFM. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Carolyn ChuFrom the Department of Family and Social Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx NY (CC, GU, PM, PAS); the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx NY (MH); the Harold and Muriel Block Institute for Clinical and Translational Research at Einstein and Montefiore, Albert Einstein College of Medicine, Bronx NY (AP); and the HIV Research Network, Johns Hopkins University School of Medicine, Baltimore, MD (CV).
Moonseong HeoFrom the Department of Family and Social Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx NY (CC, GU, PM, PAS); the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx NY (MH); the Harold and Muriel Block Institute for Clinical and Translational Research at Einstein and Montefiore, Albert Einstein College of Medicine, Bronx NY (AP); and the HIV Research Network, Johns Hopkins University School of Medicine, Baltimore, MD (CV). moonseong.heo@einstein.yu.edu.
Alex PeshanskyFrom the Department of Family and Social Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx NY (CC, GU, PM, PAS); the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx NY (MH); the Harold and Muriel Block Institute for Clinical and Translational Research at Einstein and Montefiore, Albert Einstein College of Medicine, Bronx NY (AP); and the HIV Research Network, Johns Hopkins University School of Medicine, Baltimore, MD (CV).
Galina UmanskiFrom the Department of Family and Social Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx NY (CC, GU, PM, PAS); the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx NY (MH); the Harold and Muriel Block Institute for Clinical and Translational Research at Einstein and Montefiore, Albert Einstein College of Medicine, Bronx NY (AP); and the HIV Research Network, Johns Hopkins University School of Medicine, Baltimore, MD (CV).
Paul MeissnerFrom the Department of Family and Social Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx NY (CC, GU, PM, PAS); the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx NY (MH); the Harold and Muriel Block Institute for Clinical and Translational Research at Einstein and Montefiore, Albert Einstein College of Medicine, Bronx NY (AP); and the HIV Research Network, Johns Hopkins University School of Medicine, Baltimore, MD (CV).
Cindy VossFrom the Department of Family and Social Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx NY (CC, GU, PM, PAS); the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx NY (MH); the Harold and Muriel Block Institute for Clinical and Translational Research at Einstein and Montefiore, Albert Einstein College of Medicine, Bronx NY (AP); and the HIV Research Network, Johns Hopkins University School of Medicine, Baltimore, MD (CV).
Peter A SelwynFrom the Department of Family and Social Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx NY (CC, GU, PM, PAS); the Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx NY (MH); the Harold and Muriel Block Institute for Clinical and Translational Research at Einstein and Montefiore, Albert Einstein College of Medicine, Bronx NY (AP); and the HIV Research Network, Johns Hopkins University School of Medicine, Baltimore, MD (CV).

Funding

Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025750 · NCRR · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SHAMOON, HARRY · 2008 to 2011
$20.5M
Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI GOLDSTEIN, HARRIS · 2003 to 2013
$18.6M
NCATS NIH HHS UL1 TR001073NCRR NIH HHS UL1 RR025750NIAID NIH HHS P30 AI051519NIAID NIH HHS P30AI051519
6 · The paper itself

Abstract

purposeThe human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome epidemic in the United States is evolving because of factors such as aging and geographic diffusion. Provider shortages are also driving the restructuring of HIV care delivery away from specialized settings, and family medicine providers may play a larger role in the future. We attempted to compare the effectiveness of HIV treatment delivered at community versus hospital care settings.

methodsThe outcome of interest was sustained virologic suppression defined as 2 consecutive HIV-1 RNA measurements ≤400 copies/mL within 1 year after antiretroviral initiation. We used data from the multistate HIV Research Network cohort to compare sustained virologic suppression outcomes among 15,047 HIV-infected adults followed from 2000 to 2008 at 5 community- and 8 academic hospital-based ambulatory care sites. Community-based sites were mostly staffed by family medicine and general internal medicine physicians with HIV expertise, whereas hospital sites were primarily staffed by infectious disease subspecialists. Multivariate mixed effects logistic regression controlling for potential confounding variables was applied to account for clustering effects of study sites.

resultsIn an unadjusted analysis the rate of sustained virologic suppression was significantly higher among subjects treated in community-based care settings: 1,646 of 2,314 (71.1%) versus 8,416 of 12,733 (66.1%) (P < .01). In the adjusted multivariate model with potential confounding variables, the rate was higher, although not statistically significant, in the community-based settings (adjusted odds ratio, 1.26; 95% confidence interval, 0.73-2.16).

conclusionAntiretroviral therapy can be delivered effectively through community-based treatment settings. This finding is potentially important for new program development, shifting HIV care into community-based settings as the landscape of accountable care, health reform, and HIV funding and resources evolves.

Indexed as

Delivery of Health CareAcademic Medical CentersAdultAntirheumatic AgentsCommunity Health CentersFemaleHIV InfectionsHumansMaleMiddle AgedTreatment OutcomeAntirheumatic AgentsHIVPrimary Health Care

Identifiers

PMID25567825
PMCPMC4456020

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.