ReviewNeuropsychology review2015
Genetics and underlying pathology of dementia.
Review in Neuropsychology review, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Genome wide association study meta-analysis of neuropathologic lesions of Alzheimer's disease and related dementias in a multi-site autopsy cohort.PLoS genetics · 2026Pooled it
- Relationship between shift work, night work, and subsequent dementia: A systematic evaluation and meta-analysis.Frontiers in neurology · 2022Pooled it
- Increased Risk for Dementia in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis of Population-Based Studies.Frontiers in neurology · 2022Pooled it
- Chronic Noise Exposure and Risk of Dementia: A Systematic Review and Dose-Response Meta-Analysis.Frontiers in public health · 2022Pooled it
- Evolutionary sex bias in cognitive response to new environmental risk factor - PM2.5.Biology of sex differences · 2025Review
- The role of the hippocampus and SLC39A8 in chronic musculoskeletal pain-induced dementia: a Mendelian randomization study.Scientific reports · 2025Article
- Article
- Latent profiles of modifiable dementia risk factors in later midlife: relationships with incident dementia, cognition, and neuroimaging outcomes.Molecular psychiatry · 2025Article
- The role of lipid metabolism in cognitive impairment.Arquivos de neuro-psiquiatria · 2025Review
- Prevalence of hearing loss in patients with dementia and its association with dementia severity.SAGE open medicine · 2025Article
- Atrial Fibrillation and Other Cardiovascular Factors and the Risk of Dementia: An Italian Case-Control Study.International journal of environmental research and public health · 2024Article
- Biomarker profiling to determine clinical impact of microRNAs in cognitive disorders.Scientific reports · 2024Article
- Sex differences in the progression to Alzheimer's disease: a combination of functional and structural markers.GeroScience · 2024Article
- Artificial intelligence approaches for early detection of neurocognitive disorders among older adults.Frontiers in computational neuroscience · 2024Article
- Diagnostic Efficacy and Clinical Relevance of Artificial Intelligence in Detecting Cognitive Decline.Cureus · 2023Review
- Extracellular Vesicles in Neurodegenerative Diseases: An Update.International journal of molecular sciences · 2023Review
- Association of stressful life events with cognitive impairment in patients with type 2 diabetes mellitus.Journal of diabetes investigation · 2023Article
- Atrial fibrillation as a contributor to the mortality in patients with dementia: A nationwide cohort study.Frontiers in cardiovascular medicine · 2023Article
- Artificial Intelligence Models in the Diagnosis of Adult-Onset Dementia Disorders: A Review.Bioengineering (Basel, Switzerland) · 2022Review
- Analysis of senescence in gingival tissues and gingival fibroblast cultures.Clinical and experimental dental research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As the population steadily ages, dementia, in all its forms, remains a great societal challenge. Yet, our knowledge of their etiology remains rather limited. To this end, genetic studies can give us insight into the underlying mechanisms that lead to the development of dementia, potentially facilitating treatments in the future. In this review we cover the most recent genetic risk factors associated with the onset of the four most common dementia types today, including Alzheimer's disease (AD), Vascular Dementia (VaD), Frontotemporal Lobar Degeneration (FTLD) and Lewy Body Dementia (LBD). Moreover, we discuss the overlap in major underlying pathologies of dementia derived from their genetic associations. While all four dementia types appear to involve genes associated with tau-pathology and neuroinflammation only LBD, AD and VaD appear to involve amyloid genes while LBD and FTLD share alpha synuclein genes. Together these findings suggest that some of the dementias may exist along a spectrum and demonstrates the necessity to conduct large-scale studies pinpointing the etiology of the dementias and potential gene and environment interactions that may influence their development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.