ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Childhood trauma and neural responses to personalized stress, favorite-food and neutral-relaxing cues in adolescents.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Problematic social media use and adverse childhood experiences: A systematic review.Journal of behavioral addictions · 2026Pooled it
- Effects of naltrexone are influenced by childhood adversity during negative emotional processing in addiction recovery.Translational psychiatry · 2017Trial
- A unified theory of restrictive and addictive eating: a life course model integrating generational transmission, neurodevelopmental risk, and ultra-processed food use disorder-a theoretical review.Journal of eating disorders · 2026Review
- Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Article
- Atypical Neural Activation During Emotional but Not Nonemotional Response Inhibition in Healthy Young People Exposed to Childhood Maltreatment and Peer Victimization.Biological psychiatry global open science · 2025Article
- The prospective associations among time management tendency, negative emotions, and problematic smartphone use in Chinese nursing students: enlightenment from COVID-19.Frontiers in public health · 2024Article
- Childhood Traumatic Experiences and Negative Alcohol-Related Consequences in Adulthood: A Cross-Cultural Examination of Distress Tolerance and Drinking to Cope.Substance use & misuse · 2023Article
- The potential addictive mechanism involved in repetitive nonsuicidal self-injury: The roles of emotion dysregulation and impulsivity in adolescents.Journal of behavioral addictions · 2022Article
- Stress-related hippocampus activation mediates the association between polyvictimization and trait anxiety in adolescents.Social cognitive and affective neuroscience · 2022Article
- Limitations of the protective measure theory in explaining the role of childhood sexual abuse in eating disorders, addictions, and obesity: an updated model with emphasis on biological embedding.Eating and weight disorders : EWD · 2022Review
- Stress-elicited neural activity in young adults varies with childhood sexual abuse.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Posttraumatic Stress Disorder and the Developing Adolescent Brain.Biological psychiatry · 2021Review
- Neural mechanisms of acute stress and trait anxiety in adolescents.NeuroImage. Clinical · 2021Article
- Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications.Nutrients · 2020Review
- Sexual Abuse in Adolescents Is Associated With Atypically Increased Responsiveness Within Regions Implicated in Self-Referential and Emotional Processing to Approaching Animate Threats.Frontiers in psychiatry · 2020Article
- Trauma-associated anterior cingulate connectivity during reward learning predicts affective and anxiety states in young adults.Psychological medicine · 2019Article
- Chronic harsh parenting and anxiety associations with fear circuitry function in healthy adolescents: A preliminary study.Biological psychology · 2019Article
- Neural Correlates of Personalized Spiritual Experiences.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Childhood trauma moderates inhibitory control and anterior cingulate cortex activation during stress.NeuroImage · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Previous studies have found childhood trauma to be associated with functional and structural abnormalities in corticostriatal-limbic brain regions, which may explain the associations between trauma and negative mental and physical health outcomes. However, functional neuroimaging of maltreatment-related trauma has been limited by largely using generic and predominantly aversive stimuli. Personalized stress, favorite-food, and neutral/relaxing cues during functional magnetic resonance imaging were used to probe the neural correlates of emotional/motivational states in adolescents with varying exposure to maltreatment-related trauma. Sixty-four adolescents were stratified into high- or low-trauma-exposed groups. Cue-related measures of subjective anxiety and craving were collected. Relative to the low-trauma-exposed group, high-trauma-exposed adolescents displayed an increased activation of insula, anterior cingulate, and prefrontal cortex in response to stress cues. Activation in subcortical structures, including the hippocampus, was inversely correlated with subjective anxiety in the high- but not the low-trauma-exposed group. The high-trauma-exposed group displayed hypoactivity of cerebellar regions in response to neutral/relaxing cues. No group differences were observed in response to favorite-food cues. The relationship between trauma exposure and altered cortico-limbic circuitry may in part explain the association between childhood trauma and heightened vulnerability to emotional disturbances and risky behaviour. This may be particularly pertinent during adolescence when such difficulties often emerge. Further work is needed to elucidate the mechanism linking trauma to obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.