ArticleInflammation2015
Inhibitory Effects of Polydatin on Lipopolysaccharide-Stimulated RAW 264.7 Cells.
Article in Inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
- Trial
- Polydatin as a natural ClpP modulator for combating methicillin-resistantFrontiers in cellular and infection microbiology · 2026Article
- Anti-Inflammatory Diterpenoids from the Aerial Parts ofACS omega · 2025Article
- Melatonin as a treatment for atherosclerosis: focus on programmed cell death, inflammation and oxidative stress.Journal of cardiothoracic surgery · 2025Review
- Nephroprotective effects of substances of medicine food homology and traditional Chinese medicine phytochemicals against acute kidney injury.Frontiers in pharmacology · 2025Review
- Article
- Peimine ameliorates LPS-induced acute lung injury by regulating Nrf2 and NF-κB pathways.American journal of translational research · 2024Article
- Multimodal Identification by Transcriptomics and Multiscale Bioassays of Active Components in Xuanfeibaidu Formula to Suppress Macrophage-Mediated Immune Response.Engineering (Beijing, China) · 2023Article
- Ganoderic Acid A Alleviates OVA-Induced Asthma in Mice.Inflammation · 2021Article
- Melatonin alleviates lipopolysaccharide-induced myocardial injury by inhibiting inflammation and pyroptosis in cardiomyocytes.Annals of translational medicine · 2021Article
- The Anti-Inflammatory Effect ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Polydatin-loaded chitosan nanoparticles ameliorates early diabetic nephropathy by attenuating oxidative stress and inflammatory responses in streptozotocin-induced diabetic rat.Journal of diabetes and metabolic disorders · 2020Article
- MALAT1 Up-Regulator Polydatin Protects Brain Microvascular Integrity and Ameliorates Stroke Through C/EBPβ/MALAT1/CREB/PGC-1α/PPARγ Pathway.Cellular and molecular neurobiology · 2019Article
- Article
- Triptriolide Alleviates Lipopolysaccharide-Induced Liver Injury by Nrf2 and NF-κB Signaling Pathways.Frontiers in pharmacology · 2018Article
- LC-MS/MS analysis and evaluation of the anti-inflammatory activity of components from BushenHuoxue decoction.Pharmaceutical biology · 2017Article
- Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivo.Journal of cellular and molecular medicine · 2017Article
- Salidroside Attenuates LPS-Induced Acute Lung Injury in Rats.Inflammation · 2017Article
- Anti-inflammatory Role of Pilose Antler Peptide in LPS-Induced Lung Injury.Inflammation · 2017Article
- Polydatin ameliorates Staphylococcus aureus-induced mastitis in mice via inhibiting TLR2-mediated activation of the p38 MAPK/NF-κB pathway.Acta pharmacologica Sinica · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to evaluate the effects of polydatin (PD) on cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) expressions at protein and transcriptional levels, as well as the production of prostaglandin E2 (PGE2) and nitric oxide (NO) in lipopolysaccharide (LPS)-induced macrophage RAW 264.7 cells. To elucidate the underlying mechanism responsible for these symptoms, we investigated the phosphorylation of mitogen-activated protein kinase (MAPK) pathway and nuclear factor-κB (NF-κB) expression. NO was analyzed with the Griess method. PGE2 was measured by enzyme-linked immunosorbent assay (ELISA). iNOS and COX-2 messenger RNA (mRNA) were identified by qPCR assay. iNOS, COX-2, NF-κB, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38 protein expressions were detected with Western blot. The results revealed that PD effectively inhibited NO and PGE2 production, and it is not surprising that PD reduced iNOS and COX-2 expression at protein and transcriptional levels. Additionally, PD significantly ameliorated the activation of NF-κB and the phosphorylation of MAPKs in LPS-induced RAW 264.7 macrophages. These findings suggested that PD exerted potent anti-inflammatory activity in macrophages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.