ArticleAging2014
Aged iPSCs display an uncommon mitochondrial appearance and fail to undergo in vitro neurogenesis.
Article in Aging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Human iPSCs from Aged Donors Retain Their Mitochondrial Aging Signature.International journal of molecular sciences · 2024Article
- Human In Vitro Models of Neuroenergetics and Neurometabolic Disturbances: Current Advances and Clinical Perspectives.Stem cells translational medicine · 2024Review
- Mitochondrial genome mutations and neuronal dysfunction of induced pluripotent stem cells derived from patients with Alzheimer's disease.Cell proliferation · 2022Article
- LINCing Senescence and Nuclear Envelope Changes.Cells · 2022Review
- Mitochondrial and Autophagic Regulation of Adult Neurogenesis in the Healthy and Diseased Brain.International journal of molecular sciences · 2021Review
- The ageing epigenome and its rejuvenation.Nature reviews. Molecular cell biology · 2020Review
- Mitochondrial and Peroxisomal Alterations Contribute to Energy Dysmetabolism in Riboflavin Transporter Deficiency.Oxidative medicine and cellular longevity · 2020Article
- Are There Common Mechanisms Between the Hutchinson-Gilford Progeria Syndrome and Natural Aging?Frontiers in genetics · 2019Review
- New Challenge: Mitochondrial Epigenetics?Stem cell reviews and reports · 2018Review
- TOR-mediated regulation of metabolism in aging.Aging cell · 2017Review
- The Potential of iPSCs for the Treatment of Premature Aging Disorders.International journal of molecular sciences · 2017Review
- Article
- Metabolic switching and cell fate decisions: implications for pluripotency, reprogramming and development.Current opinion in genetics & development · 2017Review
- Aged induced pluripotent stem cell (iPSCs) as a new cellular model for studying premature aging.Aging · 2017Article
- Eat, breathe, ROS: controlling stem cell fate through metabolism.Expert review of cardiovascular therapy · 2017Review
- Mitochondrial Heterogeneity: Evaluating Mitochondrial Subpopulation Dynamics in Stem Cells.Stem cells international · 2017Review
- Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells.Aging · 2016Article
- Energy Metabolism Plays a Critical Role in Stem Cell Maintenance and Differentiation.International journal of molecular sciences · 2016Review
- Review
- Connecting Mitochondria, Metabolism, and Stem Cell Fate.Stem cells and development · 2015Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reprogramming of human fibroblasts into induced pluripotent stem cells (iPSCs) leads to mitochondrial rejuvenation, making iPSCs a candidate model to study the mitochondrial biology during stemness and differentiation. At present, it is generally accepted that iPSCs can be maintained and propagated indefinitely in culture, but no specific studies have addressed this issue. In our study, we investigated features related to the 'biological age' of iPSCs, culturing and analyzing iPSCs kept for prolonged periods in vitro. We have demonstrated that aged iPSCs present an increased number of mitochondria per cell with an altered mitochondrial membrane potential and fail to properly undergo in vitro neurogenesis. In aged iPSCs we have also found an altered expression of genes relevant to mitochondria biogenesis. Overall, our results shed light on the mitochondrial biology of young and aged iPSCs and explore how an altered mitochondrial status may influence neuronal differentiation. Our work suggests to deepen the understanding of the iPSCs biology before considering their use in clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.