ArticleCurrent treatment options in gastroenterology2015
Clostridium difficile infection: risk factors, diagnosis and management.
Article in Current treatment options in gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Risk factors forJournal of global health · 2017Pooled it
- Predictors of Clostridium difficile infection after stoma reversal following TaTME surgery.Updates in surgery · 2023Article
- Burden ofIranian journal of public health · 2019Review
- Impact of superimposed Clostridium difficile infection in Crohn's or ulcerative colitis flares in the outpatient setting.International journal of colorectal disease · 2018Article
- Amelioration of Clostridium difficile Infection in Mice by Dietary Supplementation With Indole-3-carbinol.Annals of surgery · 2017Article
- Successful Therapy of Severe Pseudomembranous Clostridium difficile Colitis Using a Combination of Fecal Microbiota Therapy and Fidaxomicin.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017Article
- A Diagnostic Algorithm for the Detection of Clostridium difficile-Associated Diarrhea.Balkan medical journal · 2016Article
- Using bugs as drugs: Microbial ecosystem therapeutics.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2015Article
- Dentists, antibiotics and Clostridium difficile-associated disease.British dental journal · 2015Review
- C. difficile Infection: Changing Epidemiology and Management Paradigms.Clinical and translational gastroenterology · 2015Article
- Clostridium difficile infection after ileostomy closure mimicking anastomotic leak.BMJ case reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
opinion statementClostridium difficile infection (CDI) is the leading cause of death due to gastrointestinal infections in the US and is the most common cause of nosocomial diarrhea. The emergence of a hypervirulent strain in the early 2000s has been associated with a dramatic increase in the number and severity of cases in the US, Canada, and several other countries. Most cases are related to antibiotic use, but sporadic cases occur in otherwise healthy individuals with no risk factors. Morbidity and mortality are highest in the elderly. Diagnosis is confirmed by detection of C. difficile toxin in the stools. Treatment should be stratified by severity of disease, with metronidazole use for mild disease cases and vancomycin for severe disease. Recurrent CDI occurs in 10-20 % of cases. A first recurrence can be treated with a ten-day regimen of metronidazole or vancomycin; a second recurrence is best treated by a pulsed regimen of vancomycin. In patients with multiple (three or more) recurrences, fecal microbiota transplant has a high rate of success. The most important methods of prevention are wise antibiotic policies, hand hygiene, isolation, and barrier methods in hospital and long-term care facilities (LCTF) settings.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.