Evidence map›Paper›PMID 25567069›Full record

Trial reportEuropean journal of nutrition2016

Effects of Brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: a randomized controlled pilot trial.

Bárbara Rita Cardoso, Daniel Apolinário, Verônica da Silva Bandeira, Alexandre Leopold Busse, Regina Miksian Magaldi, Wilson Jacob-Filho, Silvia Maria Franciscato Cozzolino

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03500601 (Effects of Daily Tree Nut Consumption on Cognitive Function, Metabolomics and Intestinal Microbiota), which is not on this map. Cited by 48 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03500601 nacompletednot on this mapstarted 2017, after this paper: background citation

Effects of Daily Tree Nut Consumption on Cognitive Function, Metabolomics and Intestinal Microbiota

TypeinterventionalSponsorNorthumbria UniversityRan2017 to 2018Enrolled81ConditionsCognitive Function, Urinary Metabolites, Intestinal MicrobiotaArmsNut components, Placebo
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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  4. Nut Consumption for Cognitive Performance: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2021
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  12. Ferroptotic neurodegeneration and diet: a narrative review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Bárbara Rita CardosoDepartment of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 580, Bloco 14, Butantã, São Paulo, 05508-000, Brazil. baritacardoso@gmail.com.
Daniel ApolinárioGeriatrics Division, Department of Internal Medicine, University of São Paulo Medical School, São Paulo, Brazil.
Verônica da Silva BandeiraDepartment of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 580, Bloco 14, Butantã, São Paulo, 05508-000, Brazil.
Alexandre Leopold BusseGeriatrics Division, Department of Internal Medicine, University of São Paulo Medical School, São Paulo, Brazil.
Regina Miksian MagaldiGeriatrics Division, Department of Internal Medicine, University of São Paulo Medical School, São Paulo, Brazil.
Wilson Jacob-FilhoGeriatrics Division, Department of Internal Medicine, University of São Paulo Medical School, São Paulo, Brazil.
Silvia Maria Franciscato CozzolinoDepartment of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes 580, Bloco 14, Butantã, São Paulo, 05508-000, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOxidative stress is closely related to cognitive impairment, and the antioxidant system may be a potential therapeutic target to preserve cognitive function in older adults. Selenium plays an important antioxidant role through selenoproteins. This controlled trial aimed to investigate the antioxidant and cognitive effects of the consumption of Brazil nuts, the best selenium food source.

methodsWe enrolled 31 older adults with mild cognitive impairment (MCI) who were randomly assigned to ingestion of Brazil nuts or to the control group. Participants of the treatment group consumed one Brazil nut daily (estimated 288.75 µg/day) for 6 months. Blood selenium concentrations, erythrocyte glutathione peroxidase (GPx) activity, oxygen radical absorbance capacity, and malondialdehyde were evaluated. Cognitive functions were assessed with the CERAD neuropsychological battery.

resultsEleven participants of the treated group and nine of the control group completed the trial. The mean age of the participants was 77.7 (±5.3) years, 70 % of whom were female. We observed increased selenium levels after the intervention, whereas the control group presented no change. Among the parameters related to the antioxidant system, only erythrocyte GPx activity change was significantly different between the groups (p = 0.006). After 6 months, improvements in verbal fluency (p = 0.007) and constructional praxis (p = 0.031) were significantly greater on the supplemented group when compared with the control group.

conclusionOur results suggest that the intake of Brazil nut restores selenium deficiency and provides preliminary evidence that Brazil nut consumption can have positive effects on some cognitive functions of older adults with MCI.

Indexed as

BertholletiaNutsAgedAged, 80 and overCholesterol, HDLCholesterol, LDLCognitionCognitive DysfunctionFemaleGlutathione PeroxidaseHumansMaleMalondialdehydeNutritional StatusOxidative StressPilot ProjectsCholesterol, HDLCholesterol, LDLGlutathione PeroxidaseMalondialdehydeSeleniumTriglyceridesBrazil nutsMild cognitive impairmentOxidative stressSelenium

Identifiers

PMID25567069

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.