ArticleRadiation oncology (London, England)2015
Analysis of motion of the rectum during preoperative intensity modulated radiation therapy for rectal cancer using cone-beam computed tomography.
Article in Radiation oncology (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Does setup on rectal wall improve rectal cancer boost radiotherapy?Radiation oncology (London, England) · 2018Trial
- Determining optimal GTV-to-PGTV margins for CT-guided dose-escalated radiotherapy with daily image guidance in locally advanced rectal cancer.Journal of applied clinical medical physics · 2026Article
- Investigation of changes in planning target volume and regression probability of rectal boost using in-silico cone-beam computed tomography-guided online-adaptive radiotherapy.Physics and imaging in radiation oncology · 2025Article
- Qualitative and quantitative evaluation of the role of CBCT in rectal cancer radiotherapy.La Radiologia medica · 2025Review
- Dealing with rectum motion during radiotherapy: How can we anticipate it?Technical innovations & patient support in radiation oncology · 2024Article
- Individual lymph node position variation for rectal cancer patients treated with long course chemoradiotherapy.Physics and imaging in radiation oncology · 2024Article
- Article
- Mesorectal motion evaluation in rectal cancer MR-guided radiotherapy: an exploratory study to quantify treatment margins.Radiation oncology (London, England) · 2023Article
- Unexpected Movement of the Esophagus across the Aorta.Diagnostics (Basel, Switzerland) · 2022Article
- Sexual organ-sparing with hydrogel spacer injections for rectal cancer radiotherapy: a feasibility pilot study.The British journal of radiology · 2021Article
- MV CBCT-Based Synthetic CT Generation Using a Deep Learning Method for Rectal Cancer Adaptive Radiotherapy.Frontiers in oncology · 2021Article
- Cone-beam computed tomography for organ motion evaluation in locally advanced rectal cancer patients.La Radiologia medica · 2021Article
- The importance of mesorectum motion in determining PTV margins in rectal cancer patients treated with neoadjuvant radiotherapy.Journal of radiation research · 2020Article
- Target volume motion during anal cancer image guided radiotherapy using cone-beam computed tomography.The British journal of radiology · 2018Article
- Comparison of volumetric-modulated arc therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in 25 fractions with conventional radiotherapy in preoperative chemoradiation for rectal cancers: a propensity score case-matched analysis.Radiation oncology (London, England) · 2017Article
- Organ preservation in rectal cancer - Challenges and future strategies.Clinical and translational radiation oncology · 2017Review
- Assessing Axis-specific Set-up Errors in Rectal Cancer Radiotherapy: A Prospective Cone-beam Computed Tomography-Based Study with Body Mass Index Correlation.Journal of medical physicsArticle
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Authors and funding
6 authors.
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Abstract
purposeThe purpose of the present study was to quantify the inter-fractional motion of the rectum and the rectal and bladder volumes using CBCT scans taken during chemoradiation therapy (CRT) for rectal cancer. Also, assessment was made for a better margin for simultaneous integrated boost - intensity modulated radiation therapy (SIB-IMRT) for rectal cancer. METHODS AND MATERIALS: There were 32 patients in this study undergoing preoperative CRT for rectal cancer. Each rectum and bladder was contoured on all planning CTs and CBCTs (day 1, 7, 13, 19, 25). The target volume was configured by adding margins (0, 3, 5, 7, 10, and 15 mm) to the rectum on planning CT. The respective percentage of rectal volume that exceeds the target volume was calculated for each of these margins. The percentage of bladder volume that exceeds the bladder volume in the planning CT and motion of the center of gravity of rectum were also analyzed.
resultsPlanning CTs and series of each 5 CBCTs for 32 patients were analyzed in this study. The rectal volume tended to shrink week after week. The mean values (± SD) in the 32 series per patient of the percentage of rectum on the CBCTs exceeding target volume in which the margins of 0, 3, 5, 7, 10, and 15 mm were added to the rectum on planning CT were 20.7 ± 12.5%, 7.2 ± 8.3%, 3.9 ± 5.9%, 2.1 ± 3.9%, 0.7 ± 1.8%, and 0.1 ± 0.3%, respectively. No association was seen between the percentage of changes of bladder volume and motion of rectal centroid.
conclusionsIn this study, we estimated the motion of the rectum using planning CT and CBCT. Ten to fifteen mm is a sufficient margin for the rectum during SIB-IMRT for rectal cancer in the supine position.
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