ArticleObesity surgery2015
Sleeve Gastrectomy Does Not Cause Hypertrophy and Reprogramming of Intestinal Glucose Metabolism in Rats.
Article in Obesity surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Peptide YY in Type 2 Diabetes: A Complementary Gut Hormone with Therapeutic Potential Beyond GLP-1.Nutrients · 2025Review
- Physical properties of food or bile redirection do not contribute to the intestinal adaptations after Roux-en-Y Gastric Bypass in rats.Obesity science & practice · 2023Article
- Article
- Regulation of body weight: Lessons learned from bariatric surgery.Molecular metabolism · 2023Review
- Vertical sleeve gastrectomy induces enteroendocrine cell differentiation of intestinal stem cells through bile acid signaling.JCI insight · 2022Article
- Revisiting the concept of incretin and enteroendocrine L-cells as type 2 diabetes mellitus treatment.Pharmacological research · 2022Review
- Enteroendocrine System and Gut Barrier in Metabolic Disorders.International journal of molecular sciences · 2022Review
- Nutrients handling after bariatric surgery, the role of gastrointestinal adaptation.Eating and weight disorders : EWD · 2022Review
- Gastrointestinal peptides in eating-related disorders.Physiology & behavior · 2021 · on this mapReview
- Alterations in Small Intestine and Liver Morphology, Immunolocalization of Leptin, Ghrelin and Nesfatin-1 as Well as Immunoexpression of Tight Junction Proteins in Intestinal Mucosa after Gastrectomy in Rat Model.Journal of clinical medicine · 2021Article
- The Phantom Satiation Hypothesis of Bariatric Surgery.Frontiers in neuroscience · 2021Article
- Glucagon-Like Peptide-1: Actions and Influence on Pancreatic Hormone Function.Comprehensive Physiology · 2020Review
- Upregulation of Intestinal NLRP6 Inflammasomes After Roux-en-Y Gastric Bypass Promotes Gut Immune Homeostasis.Obesity surgery · 2020Article
- Additional effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomy.Surgery today · 2019Article
- Mechanisms for the metabolic success of bariatric surgery.Journal of neuroendocrinology · 2019Review
- Mechanisms Underlying Type 2 Diabetes Remission After Metabolic Surgery.Frontiers in endocrinology · 2019Review
- Roux-en-Y Gastric Bypass Surgery-Induced Weight Loss and Metabolic Improvements Are Similar in TGR5-Deficient and Wildtype Mice.Obesity surgery · 2018Article
- Weight-Independent Mechanisms of Glucose Control After Roux-en-Y Gastric Bypass.Frontiers in endocrinology · 2018Review
- The Role of GLP-1 in the Metabolic Success of Bariatric Surgery.Endocrinology · 2017Review
- Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundClinical studies have shown similar rapid improvements in body mass and glycemic control after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG). Evidence suggests that adaptive intestinal tissue growth and reprogramming of intestinal glucose disposal play a key role in the beneficial effects on glucose homeostasis after RYGB, but it is not known whether such adaptive changes also occur after sleeve gastrectomy.
methodsHigh-fat diet-induced obese rats were subjected to either VSG or RYGB, and intestinal growth and functional adaptations were assessed by using morphometric, immunohistochemical, and immuno-blot techniques, 3 months after surgery or sham surgery.
resultsThe cross-sectional areas of the Roux and common limbs are significantly increased after RYGB compared with sham surgery (Roux limb: 17.1 ± 4.0 vs. 5.5 ± 0.1 mm(2); common limb: 11.7 ± 0.6 vs. 5.1 ± 0.5 mm(2); p < 0.01), but the cross-sectional area of the corresponding jejunum is not different from controls after VSG. Similarly, mucosal thickness and the number of GLP-1 cells are not increased after VSG. Protein expression of hexokinase II is increased fourfold (p < 0.01) in the Roux limb after RYGB, but not in the jejunum after VSG.
conclusionsAdaptive hypertrophy and reprogramming of glucose metabolism in the small intestine are not necessary for VSG to improve body composition and glycemic control. The similar beneficial effects of VSG and RYGB on glucose homeostasis might be mediated by different mechanisms.
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