ArticleHistochemistry and cell biology2015
Placental fractalkine mediates adhesion of THP-1 monocytes to villous trophoblast.
Article in Histochemistry and cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Fractalkine (Chemokine CX3CL1) Signaling During Placentation and Placental Function.International journal of molecular sciences · 2026Review
- CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis.International journal of molecular sciences · 2024Review
- Culture and Maintenance of Immune Cells to Model Innate Immune Status at the Feto-maternal Interface.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Immune checkpoint molecules B7-1 and B7-H1 as predictive markers of pre-eclampsia: A case-control study in a Ghana.Immunity, inflammation and disease · 2024Article
- The potential association between a new angiogenic marker fractalkine and a placental vascularization in preeclampsia.Archives of gynecology and obstetrics · 2021Observational
- Is there an inflammatory stimulus to human term labour?PloS one · 2021Article
- Data-driven discovery of mid-pregnancy immune markers associated with maternal lifetime stress: results from an urban pre-birth cohort.Stress (Amsterdam, Netherlands) · 2020Article
- The Role of Inflammation in the Pathogenesis of Preeclampsia.Mediators of inflammation · 2020Review
- Maternal Platelets—Friend or Foe of the Human Placenta?International journal of molecular sciences · 2019Review
- Role of the Monocyte-Macrophage System in Normal Pregnancy and Preeclampsia.International journal of molecular sciences · 2019Review
- Placental CX3CL1 is Deregulated by Angiotensin II and Contributes to a Pro-Inflammatory Trophoblast-Monocyte Interaction.International journal of molecular sciences · 2019Article
- Plasmodium falciparum proteins involved in cytoadherence of infected erythrocytes to chemokine CX3CL1.Scientific reports · 2016Article
- Prolonged activation of innate antiviral gene signature after childbirth is determined by IFNL3 genotype.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The role of CX3CL1 in fetal-maternal interaction during human gestation.Cell adhesion & migration · 2016Review
- The Histochemistry and Cell Biology omnium-gatherum: the year 2015 in review.Histochemistry and cell biology · 2016Review
- Cellular Regulation of the Uterine Microenvironment That Enables Embryo Implantation.Frontiers in immunology · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
The chemokine fractalkine (CX3CL1) recently attracted increasing attention in the field of placenta research due to its dual nature, acting both as membrane-bound and soluble forms. While the membrane-bound form mediates flow-resistant adhesion of leukocytes to endothelial and epithelial cells via its corresponding receptor CX3CR1, the soluble form arises from metalloprotease-dependent shedding and bears chemoattractive activity for monocytes, natural killer cells and T cells. In human placenta, fractalkine is expressed at the apical microvillous plasma membrane of the syncytiotrophoblast, which may enable close physical contact with circulating maternal leukocytes. Based on these observations, we tested the hypothesis that fractalkine mediates adhesion of monocytes to the villous trophoblast. Forskolin-induced differentiation and syncytialization of the trophoblast cell line BeWo was accompanied with a substantial upregulation in fractalkine expression and led to increased adhesion of the monocyte cell line THP-1, which preferentially bound to syncytia. Blocking as well as silencing of the fractalkine receptor CX3CR1 proved involvement of the fractalkine/CX3CR1 system in adherence of THP-1 monocytes to villous trophoblast. Pre-incubation of THP-1 monocytes with human recombinant fractalkine as well as silencing of CX3CR1 expression in THP-1 monocytes significantly impaired their adherence to BeWo cells and primary term trophoblasts. The present study suggests fractalkine as another candidate among the panel of adhesion molecules enabling stable interaction between leukocytes and the syncytiotrophoblast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.