ReviewFrontiers in immunology2014
The role of nucleotides and purinergic signaling in apoptotic cell clearance - implications for chronic inflammatory diseases.
Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration.Bioactive materials · 2025Review
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- Dendritic cell maturation in cancer.Nature reviews. Cancer · 2025Review
- Activation of Purinergic P2Y2 Receptor Protects the Kidney Against Renal Ischemia and Reperfusion Injury in Mice.International journal of molecular sciences · 2024Article
- Pannexin1 Channel-Mediated Inflammation in Acute Ischemic Stroke.Aging and disease · 2024Review
- The ATP-dependent Pathways and Human Diseases.Current medicinal chemistry · 2023Article
- Altered CaInternational journal of molecular sciences · 2020Review
- Review
- The clearance of dead cells by efferocytosis.Nature reviews. Molecular cell biology · 2020Review
- Priming of Anti-tumor Immune Mechanisms by Radiotherapy Is Augmented by Inhibition of Heat Shock Protein 90.Frontiers in oncology · 2020Article
- Updating osteoimmunology: regulation of bone cells by innate and adaptive immunity.Nature reviews. Rheumatology · 2018Review
- Anti-inflammatory effects of Lefty-1 in renal tubulointerstitial inflammation via regulation of the NF-κB pathway.International journal of molecular medicine · 2018Article
- Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice.Journal of neuroinflammation · 2018Article
- Article
- Inosine Released from Dying or Dead Cells Stimulates Cell ProliferationFrontiers in immunology · 2017Article
- Cell viability, reactive oxygen species, apoptosis, and necrosis in myoblast cultures exposed to low-level infrared laser.Lasers in medical science · 2016Article
- A1 adenosine receptor attenuates intracerebral hemorrhage-induced secondary brain injury in rats by activating the P38-MAPKAP2-Hsp27 pathway.Molecular brain · 2016Article
- Suramin protects from cisplatin-induced acute kidney injury.American journal of physiology. Renal physiology · 2016Article
- Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective.International journal of molecular sciences · 2015Review
- The Sound of Silence: Signaling by Apoptotic Cells.Current topics in developmental biology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Billions of cells undergo apoptosis every day in healthy individuals. A prompt removal of dying cells prevents the release of pro-inflammatory intracellular content and progress to secondary necrosis. Thus, inappropriate clearance of apoptotic cells provokes autoimmunity and has been associated with many chronic inflammatory diseases. Recent studies have suggested that extracellular adenosine 5'-triphosphate and related nucleotides play an important role in the apoptotic clearance process. Here, we review the current understanding of nucleotides and purinergic receptors in apoptotic cell clearance and the potential therapeutic targets of purinergic receptor subtypes in inflammatory conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.