ArticleFrontiers in microbiology2014
Transcription factors FabR and FadR regulate both aerobic and anaerobic pathways for unsaturated fatty acid biosynthesis in Shewanella oneidensis.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 29 citations in OpenAlex.
- A bacterial transcription activator dedicated to the expression of the enzyme catalyzing the first committed step in fatty acid biosynthesis.Nucleic acids research · 2024Article
- Regulation of fadR on the ROS defense mechanism in Shewanalla oneidensis.Biotechnology letters · 2024Article
- Investigation of Acid Tolerance Mechanism ofFoods (Basel, Switzerland) · 2023Article
- The Escherichia coli FadR transcription factor: Too much of a good thing?Molecular microbiology · 2021Review
- Genetic Suppression of Lethal Mutations in Fatty Acid Biosynthesis Mediated by a Secondary Lipid Synthase.Applied and environmental microbiology · 2021Article
- A transcriptome analysis of the antibacterial mechanism of flavonoids from Sedum aizoon L. against Shewanella putrefaciens.World journal of microbiology & biotechnology · 2020Article
- Adaptation of the Marine BacteriumInternational journal of molecular sciences · 2020Article
- Genetic regulation of the bacterial omega-3 polyunsaturated fatty acid biosynthesis pathway.Journal of bacteriology · 2020Article
- Thioesterase YbgC affects motility by modulating c-di-GMP levels in Shewanella oneidensis.Scientific reports · 2017Article
- Suppression of fabB Mutation by fabF1 Is Mediated by Transcription Read-through in Shewanella oneidensis.Journal of bacteriology · 2016Article
- Shewanella oneidensis FabB: A β-ketoacyl-ACP Synthase That Works with C16:1-ACP.Frontiers in microbiology · 2016Article
- Binding of Shewanella FadR to the fabA fatty acid biosynthetic gene: implications for contraction of the fad regulon.Protein & cell · 2015Article
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4 authors at 1 institution in 1 country.
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Abstract
As genes for type II fatty acid synthesis are essential to the growth of Escherichia coli, its sole (anaerobic) pathway has significant potential as a target for novel antibacterial drug, and has been extensively studied. Despite this, we still know surprisingly little about fatty acid synthesis in bacteria because this anaerobic pathway in fact is not widely distributed. In this study, we show a novel model of unsaturated fatty acid (UFA) synthesis in Shewanella, emerging human pathogens in addition to well-known metal reducers. We identify both anaerobic and aerobic UFA biosynthesis pathways in the representative species, S. oneidensis. Uniquely, the bacterium also contains two regulators FabR and FadR, whose counterparts in other bacteria control the anaerobic pathway. However, we show that in S. oneidensis these two regulators are involved in regulation of both pathways, in either direct or indirect manner. Overall, our results indicate that the UFA biosynthesis and its regulation are far more complex than previously expected, and S. oneidensis serves as a good research model for further work.
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