ArticleFrontiers in microbiology2014
Transcriptomic analysis of Staphylococcus xylosus in the presence of nitrate and nitrite in meat reveals its response to nitrosative stress.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Genomic characterization of a multidrug-resistantFrontiers in microbiology · 2025Article
- Whole genome sequence and comparative genomics analysis of multidrug-resistant Staphylococcus xylosus NM36 isolated from a cow with mastitis in Basrah city.Journal, genetic engineering & biotechnology · 2023Article
- Staphylococcus xylosus and Staphylococcus aureus as commensals and pathogens on murine skin.Laboratory animal research · 2023Review
- Comprehensive Approaches for the Search and Characterization of Staphylococcins.Microorganisms · 2023Article
- Development of Healthier and Functional Dry Fermented Sausages: Present and Future.Foods (Basel, Switzerland) · 2022Review
- Investigating Extracellular DNA Release inMicroorganisms · 2021Article
- Transcriptomic Analysis ofMicroorganisms · 2020Article
- Selection and Evaluation ofMicroorganisms · 2020Article
- Proteome Response ofFrontiers in microbiology · 2018Article
- Species Pervasiveness Within the Group of Coagulase-Negative Staphylococci Associated With Meat Fermentation Is Modulated by pH.Frontiers in microbiology · 2018Article
- Insight into the Genome of Staphylococcus xylosus, a Ubiquitous Species Well Adapted to Meat Products.Microorganisms · 2017Review
- Evidence for Nitric Oxide Synthase Activity inFrontiers in microbiology · 2017Article
- Adaptation of Staphylococcus xylosus to Nutrients and Osmotic Stress in a Salted Meat Model.Frontiers in microbiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcus xylosus is one of the major starter cultures used for meat fermentation because of its crucial role in the reduction of nitrate to nitrite which contributes to color and flavor development. Despite longstanding use of these additives, their impact on the physiology of S. xylosus has not yet been explored. We present the first in situ global gene expression profile of S. xylosus in meat supplemented with nitrate and nitrite at the levels used in the meat industry. More than 600 genes of S. xylosus were differentially expressed at 24 or 72 h of incubation. They represent more than 20% of the total genes and let us to suppose that addition of nitrate and nitrite to meat leads to a global change in gene expression. This profile revealed that S. xylosus is subject to nitrosative stress caused by reactive nitrogen species (RNS) generated from nitrate and nitrite. To overcome this stress, S. xylosus has developed several oxidative stress resistance mechanisms, such as modulation of the expression of several genes involved in iron homeostasis and in antioxidant defense. Most of which belong to the Fur and PerR regulons, respectively. S. xylosus has also counteracted this stress by developing DNA and protein repair. Furthermore, it has adapted its metabolic response-carbon and nitrogen metabolism, energy production and cell wall biogenesis-to the alterations produced by nitrosative stress.
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