ArticleFrontiers in microbiology2014
LDS1-produced oxylipins are negative regulators of growth, conidiation and fumonisin synthesis in the fungal maize pathogen Fusarium verticillioides.
Article in Frontiers in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 49 citations in OpenAlex.
- Biosynthesis Regulation of Secondary Metabolite Production inJournal of fungi (Basel, Switzerland) · 2025Review
- The Impact of Biocontrol Agents on the Metabolome ofToxins · 2025Article
- Plant oxylipins: adaptation to environmental stresses and impact on mycotoxin contamination.Frontiers in plant science · 2025Review
- Modulation of Virulence-Associated Traits inMicroorganisms · 2022Article
- Fungal and bacterial oxylipins are signals for intra- and inter-cellular communication within plant disease.Frontiers in plant science · 2022Review
- Aflatoxin Biosynthesis, Genetic Regulation, Toxicity, and Control Strategies: A Review.Journal of fungi (Basel, Switzerland) · 2021Review
- Unfolded Protein Response and Scaffold Independent Pheromone MAP Kinase Signaling ControlJournal of fungi (Basel, Switzerland) · 2021Article
- The Effect ofInternational journal of molecular sciences · 2021Article
- Hallmarks of Basidiomycete Soft- and White-Rot in Wood-Decay -Omics Data of TwoMicroorganisms · 2021Article
- Lipid Signaling Modulates the Response to Fumonisin Contamination and Its Source,Frontiers in plant science · 2021Article
- Fungal oxylipins direct programmed developmental switches in filamentous fungi.Nature communications · 2020Article
- Oxylipins from both pathogen and host antagonize jasmonic acid-mediated defence via the 9-lipoxygenase pathway in Fusarium verticillioides infection of maize.Molecular plant pathology · 2018Article
- Lipid Profile ofFrontiers in microbiology · 2018Article
- Article
- Transcriptome Analyses Shed New Insights into Primary Metabolism and Regulation ofFrontiers in plant science · 2017Article
- Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity.Journal of microbiology (Seoul, Korea) · 2016Review
- Article
- Menadione-Induced Oxidative Stress Re-Shapes the Oxylipin Profile of Aspergillus flavus and Its Lifestyle.Toxins · 2015Article
- Open Field Study of Some Zea mays Hybrids, Lipid Compounds and Fumonisins Accumulation.Toxins · 2015Article
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12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxylipins are fatty acid-derived signaling compounds produced by all eukaryotes so far investigated; in mycotoxigenic fungi, they modulate toxin production and interactions with the host plants. Among the many enzymes responsible for oxylipin generation, Linoleate Diol Synthase 1 (LDS1) produces mainly 8-hydroperoxyoctadecenoic acid and subsequently different di-hydroxyoctadecenoic acids. In this study, we inactivated a copy of the putative LDS1 ortholog (acc. N. FVEG_09294.3) of Fusarium verticillioides, with the aim to investigate its influence on the oxylipin profile of the fungus, on its development, secondary metabolism and virulence. LC-MS/MS oxylipin profiling carried out on the selected mutant strain revealed significant quali-quantitative differences for several oxylipins when compared to the WT strain. The Fvlds1-deleted mutant grew better, produced more conidia, synthesized more fumonisins and infected maize cobs faster than the WT strain. We hypothesize that oxylipins may act as regulators of gene expression in the toxigenic plant pathogen F. verticillioides, in turn causing notable changes in its phenotype. These changes could relate to the ability of oxylipins to re-shape the transcriptional profile of F. verticillioides by inducing chromatin modifications and exerting a direct control on the transcription of secondary metabolism in fungi.
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