ArticleFrontiers in neurology2014
Control of abnormal synchronization in neurological disorders.
Article in Frontiers in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 84 citations in OpenAlex.
- Short-term efficacy of peripheral nerve stimulation for essential tremor in a randomized double-blind controlled trial.Scientific reports · 2025Trial
- Proportional-Integral Controller-Based Deep Brain Stimulation Strategy for Controlling Excitatory-Inhibitory Network Synchronization.Proceedings of the ... American Control Conference. American Control Conference · 2025Article
- Optimal control for stochastic neural oscillators.Biological cybernetics · 2025Article
- Magnitude-constrained optimal chaotic desynchronization of neural populations.Frontiers in network physiology · 2025Article
- Exploring the synchronization of cortical networks via entrainment to intrinsic frequencies.Heliyon · 2024Article
- Resilience of the slow component in timescale-separated synchronized oscillators.Frontiers in network physiology · 2024Article
- Loss of neuron network coherence induced by virus-infected astrocytes: a model study.Scientific reports · 2023Article
- Whole-brain dynamical modelling for classification of Parkinson's disease.Brain communications · 2023Article
- Coupled and Synchronization Models of Rhythmic Arm Movement in Planar Plane.Bioengineering (Basel, Switzerland) · 2022Article
- Non-invasive electrical stimulation of peripheral nerves for the management of tremor.Journal of the neurological sciences · 2022Review
- Population temporal structure supplements the rate code during sensorimotor transformations.Current biology : CB · 2022Article
- Subthreshold repetitive transcranial magnetic stimulation suppresses ketamine-induced poly population spikes in rat sensorimotor cortex.Frontiers in neuroscience · 2022Article
- Efficient suppression of parkinsonian beta oscillations in a closed-loop model of deep brain stimulation with amplitude modulation.Frontiers in human neuroscience · 2022Article
- Technology of deep brain stimulation: current status and future directions.Nature reviews. Neurology · 2021Review
- Neural diffusivity and pre-emptive epileptic seizure intervention.PLoS computational biology · 2020Article
- Transcutaneous Afferent Patterned Stimulation Therapy Reduces Hand Tremor for One Hour in Essential Tremor Patients.Frontiers in neuroscience · 2020Article
- The Appearance Order of Varying Intervals Introduces Extra Modulation Effects on Neuronal Firing Through Non-linear Dynamics of Sodium Channels During High-Frequency Stimulations.Frontiers in neuroscience · 2020Article
- Small Changes in Inter-Pulse-Intervals Can Cause Synchronized Neuronal Firing During High-Frequency Stimulations in Rat Hippocampus.Frontiers in neuroscience · 2019Article
- Controlling Synchronization of Spiking Neuronal Networks by Harnessing Synaptic Plasticity.Frontiers in computational neuroscience · 2019Article
- Neurobiological Mechanisms of Metacognitive Therapy - An Experimental Paradigm.Frontiers in psychology · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the nervous system, synchronization processes play an important role, e.g., in the context of information processing and motor control. However, pathological, excessive synchronization may strongly impair brain function and is a hallmark of several neurological disorders. This focused review addresses the question of how an abnormal neuronal synchronization can specifically be counteracted by invasive and non-invasive brain stimulation as, for instance, by deep brain stimulation for the treatment of Parkinson's disease, or by acoustic stimulation for the treatment of tinnitus. On the example of coordinated reset (CR) neuromodulation, we illustrate how insights into the dynamics of complex systems contribute to successful model-based approaches, which use methods from synergetics, non-linear dynamics, and statistical physics, for the development of novel therapies for normalization of brain function and synaptic connectivity. Based on the intrinsic multistability of the neuronal populations induced by spike timing-dependent plasticity (STDP), CR neuromodulation utilizes the mutual interdependence between synaptic connectivity and dynamics of the neuronal networks in order to restore more physiological patterns of connectivity via desynchronization of neuronal activity. The very goal is to shift the neuronal population by stimulation from an abnormally coupled and synchronized state to a desynchronized regime with normalized synaptic connectivity, which significantly outlasts the stimulation cessation, so that long-lasting therapeutic effects can be achieved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.