ArticleFrontiers in physiology2014
A multiscale chemo-electro-mechanical skeletal muscle model to analyze muscle contraction and force generation for different muscle fiber arrangements.
Article in Frontiers in physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- A Systematic Review and Meta-Analysis on the Longitudinal Effects of Unilateral Knee Extension Exercise on Muscle Strength.Frontiers in sports and active living · 2020Pooled it
- Mechanochemical modeling of exercise-induced skeletal muscle hypertrophy.PLoS computational biology · 2026Article
- Multiscale Modeling and Analysis of Muscle Tissue: A Finite Element Approach for 3D Braided Composite Structures.Biomimetics (Basel, Switzerland) · 2026Article
- Advancements in Understanding Spasticity: A Neuromusculoskeletal Modeling Perspective.Journal of clinical medicine · 2025Review
- Data-informed reconstruction of a bipennate muscle's aponeurosis and its fibre distribution for performing continuum-mechanical simulations.Biomechanics and modeling in mechanobiology · 2025Article
- Constitutive Models for Active Skeletal Muscle: Review, Comparison, and Application in a Novel Continuum Shoulder Model.International journal for numerical methods in biomedical engineering · 2025Review
- A chemo-mechanical constitutive model for muscle activation in bat wing skins.Journal of the Royal Society, Interface · 2024Article
- Modelling motor units in 3D: influence on muscle contraction and joint force via a proof of concept simulation.Biomechanics and modeling in mechanobiology · 2023Article
- Linking cortex and contraction-Integrating models along the corticomuscular pathway.Frontiers in physiology · 2023Article
- What programs the size of animal cells?Frontiers in cell and developmental biology · 2022Review
- Intramuscular pressure of human tibialis anterior muscle detects age-related changes in muscle performance.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2021Article
- InverseMuscleNET: Alternative Machine Learning Solution to Static Optimization and Inverse Muscle Modeling.Frontiers in computational neuroscience · 2021Article
- Characterization of Electromechanical Delay Based on a Biophysical Multi-Scale Skeletal Muscle Model.Frontiers in physiology · 2019Article
- A Systematic Review of Continuum Modeling of Skeletal Muscles: Current Trends, Limitations, and Recommendations.Applied bionics and biomechanics · 2018Review
- An Efficient Modelling-Simulation-Analysis Workflow to Investigate Stump-Socket Interaction Using Patient-Specific, Three-Dimensional, Continuum-Mechanical, Finite Element Residual Limb Models.Frontiers in bioengineering and biotechnology · 2018Article
- Enabling Detailed, Biophysics-Based Skeletal Muscle Models on HPC Systems.Frontiers in physiology · 2018Article
- A continuum-mechanical skeletal muscle model including actin-titin interaction predicts stable contractions on the descending limb of the force-length relation.PLoS computational biology · 2017Article
- Elucidating Sensorimotor Control Principles with Myoelectric Musculoskeletal Models.Frontiers in human neuroscience · 2017Review
- Multiscale musculoskeletal modelling, data-model fusion and electromyography-informed modelling.Interface focus · 2016Article
- The Role of Parvalbumin, Sarcoplasmatic Reticulum Calcium Pump Rate, Rates of Cross-Bridge Dynamics, and Ryanodine Receptor Calcium Current on Peripheral Muscle Fatigue: A Simulation Study.Computational and mathematical methods in medicine · 2016Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The presented chemo-electro-mechanical skeletal muscle model relies on a continuum-mechanical formulation describing the muscle's deformation and force generation on the macroscopic muscle level. Unlike other three-dimensional models, the description of the activation-induced behavior of the mechanical model is entirely based on chemo-electro-mechanical principles on the microscopic sarcomere level. Yet, the multiscale model reproduces key characteristics of skeletal muscles such as experimental force-length and force-velocity data on the macroscopic whole muscle level. The paper presents the methodological approaches required to obtain such a multiscale model, and demonstrates the feasibility of using such a model to analyze differences in the mechanical behavior of parallel-fibered muscles, in which the muscle fibers either span the entire length of the fascicles or terminate intrafascicularly. The presented results reveal that muscles, in which the fibers span the entire length of the fascicles, show lower peak forces, more dispersed twitches and fusion of twitches at lower stimulation frequencies. In detail, the model predicted twitch rise times of 38.2 and 17.2 ms for a 12 cm long muscle, in which the fibers span the entire length of the fascicles and with twelve fiber compartments in series, respectively. Further, the twelve-compartment model predicted peak twitch forces that were 19% higher than in the single-compartment model. The analysis of sarcomere lengths during fixed-end single twitch contractions at optimal length predicts rather small sarcomere length changes. The observed lengths range from 75 to 111% of the optimal sarcomere length, which corresponds to a region with maximum filament overlap. This result suggests that stability issues resulting from activation-induced stretches of non-activated sarcomeres are unlikely in muscles with passive forces appearing at short muscle length.
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