ArticleFrontiers in aging neuroscience2014
Feasibility of resistance training in adult McArdle patients: clinical outcomes and muscle strength and mass benefits.
Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- No effect of triheptanoin on exercise performance in McArdle disease.Annals of clinical and translational neurology · 2019Trial
- An exercise intervention in children and young adults with McArdle disease: feasibility, acceptability, and clinical outcomes.Orphanet journal of rare diseases · 2026Article
- Physical exercise intervention in glycogen storage disease IIIa: Feasibility and multisystem benefits.Experimental physiology · 2026Article
- Physical exercise in metabolic myopathies at risk of rhabdomyolysis: a feasible approach or an unavoidable hazard?European journal of applied physiology · 2025Review
- Impact of individualized and supervised strength training on muscle physiology, metabolic control and quality of life in metabolic myopathies.Scientific reports · 2025Article
- Review
- The effect of systematic exercise training on skeletal muscle strength in a patient with advanced inclusion body myositis: A case study.South African journal of sports medicine · 2022Article
- Pain Phenotypes in Rare Musculoskeletal and Neuromuscular Diseases.Neuroscience and biobehavioral reviews · 2021Review
- Sex Differences and the Influence of an Active Lifestyle on Adiposity in Patients with McArdle Disease.International journal of environmental research and public health · 2020Article
- Physiological aspects of muscular adaptations to training translated to neuromuscular diseases.Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology · 2019Article
- McArdle Disease: New Insights into Its Underlying Molecular Mechanisms.International journal of molecular sciences · 2019Review
- Combined HIIT and Resistance Training in Very Long-Chain Acyl-CoA Dehydrogenase Deficiency: A Case Report.Frontiers in physiology · 2019Article
- Non-osteogenic muscle hypertrophy in children with McArdle disease.Journal of inherited metabolic disease · 2018Article
- Myopathies Related to Glycogen Metabolism Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Resistance Exercise Training in McArdle Disease: Myth or Reality?Case reports in neurological medicine · 2018Article
- Treatment Opportunities in Patients With Metabolic Myopathies.Current treatment options in neurology · 2017Review
- Skeletal muscle disorders of glycogenolysis and glycolysis.Nature reviews. Neurology · 2016Review
- Dietary Protein Intake and Lean Muscle Mass in Survivors of Childhood Acute Lymphoblastic Leukemia: Report From the St. Jude Lifetime Cohort Study.Physical therapy · 2016Article
- Rodent models for resolving extremes of exercise and health.Physiological genomics · 2016Review
- Sodium valproate increases the brain isoform of glycogen phosphorylase: looking for a compensation mechanism in McArdle disease using a mouse primary skeletal-muscle culture in vitro.Disease models & mechanisms · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed the effects of a 4-month resistance (weight lifting) training program followed by a 2-month detraining period in 7 adult McArdle patients (5 female) on: muscle mass (assessed by DXA), strength, serum creatine kinase (CK) activity and clinical severity. Adherence to training was ≥84% in all patients and no major contraindication or side effect was noted during the training or strength assessment sessions. The training program had a significant impact on total and lower extremities' lean mass (P < 0.05 for the time effect), with mean values increasing with training by +855 g (95% confidence interval (CI): 30, 1679) and +547 g (95%CI: 116, 978), respectively, and significantly decreasing with detraining. Body fat showed no significant changes over the study period. Bench press and half-squat performance, expressed as the highest value of average muscle power (W) or force (N) in the concentric-repetition phase of both tests showed a consistent increase over the 4-month training period, and decreased with detraining. Yet muscle strength and power detraining values were significantly higher than pre-training values, indicating that a training effect was still present after detraining. Importantly, all the participants, with no exception, showed a clear gain in muscle strength after the 4-month training period, e.g., bench press: +52 W (95% CI: 13, 91); half-squat: +173 W (95% CI: 96, 251). No significant time effect (P > 0.05) was noted for baseline or post strength assessment values of serum CK activity, which remained essentially within the range reported in our laboratory for McArdle patients. All the patients changed to a lower severity class with training, such that none of them were in the highest disease severity class (3) after the intervention and, as such, they did not have fixed muscle weakness after training. Clinical improvements were retained, in all but one patient, after detraining, such that after detraining all patients were classed as class 1 for disease severity.
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