Evidence map›Paper›PMID 25566066›Full record

ArticleFrontiers in aging neuroscience2014

Differential expression of sirtuin family members in the developing, adult, and aged rat brain.

Elena Sidorova-Darmos, Robert G Wither, Natalya Shulyakova, Carl Fisher, Melanie Ratnam, Michelle Aarts, Lothar Lilge, Philippe P Monnier, James H Eubanks

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 98 citations in OpenAlex.

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  4. Sirtuins, redox, and metabolic pathways in the brain of female PCOS mice.Journal of assisted reproduction and genetics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Elena Sidorova-DarmosDivision of Genetics and Development, Toronto Western Research Institute Toronto, ON, Canada ; Department of Physiology, University of Toronto Toronto, ON, Canada.
Robert G WitherDivision of Genetics and Development, Toronto Western Research Institute Toronto, ON, Canada.
Natalya ShulyakovaDivision of Genetics and Development, Toronto Western Research Institute Toronto, ON, Canada ; Department of Physiology, University of Toronto Toronto, ON, Canada.
Carl FisherDepartment of Medical Biophysics, University of Toronto Toronto, ON, Canada.
Melanie RatnamDepartment of Cell Systems Biology, University of Toronto Toronto, ON, Canada.
Michelle AartsDepartment of Cell Systems Biology, University of Toronto Toronto, ON, Canada.
Lothar LilgeDepartment of Medical Biophysics, University of Toronto Toronto, ON, Canada.
Philippe P MonnierDivision of Genetics and Development, Toronto Western Research Institute Toronto, ON, Canada ; Department of Physiology, University of Toronto Toronto, ON, Canada.
James H EubanksDivision of Genetics and Development, Toronto Western Research Institute Toronto, ON, Canada ; Department of Physiology, University of Toronto Toronto, ON, Canada ; Institute of Medical Sciences, University of Toronto Toronto, ON, Canada ; Department of Surgery (Neurosurgery), University of Toronto Toronto, ON, Canada.
University of Toronto · CAToronto Western Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The sirtuins are NAD(+)-dependent protein deacetylases and/or ADP-ribosyltransferases that play roles in metabolic homeostasis, stress response and potentially aging. This enzyme family resides in different subcellular compartments, and acts on a number of different targets in the nucleus, cytoplasm and in the mitochondria. Despite their recognized ability to regulate metabolic processes, the roles played by specific sirtuins in the brain-the most energy demanding tissue in the body-remains less well investigated and understood. In the present study, we examined the regional mRNA and protein expression patterns of individual sirtuin family members in the developing, adult, and aged rat brain. Our results show that while each sirtuin is expressed in the brain at each of these different stages, they display unique spatial and temporal expression patterns within the brain. Further, for specific members of the family, the protein expression profile did not coincide with their respective mRNA expression profile. Moreover, using primary cultures enriched for neurons and astrocytes respectively, we found that specific sirtuin members display preferential neural lineage expression. Collectively, these results provide the first composite illustration that sirtuin family members display differential expression patterns in the brain, and provide evidence that specific sirtuins could potentially be targeted to achieve cell-type selective effects within the brain.

Indexed as

agingastrocytedevelopmentexpressionimmunoblotneuronreal time PCRsirtuin

Identifiers

PMID25566066
PMCPMC4270178
OpenAlexW1973831249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.