ReviewFrontiers in human neuroscience2014
Abnormal asymmetry of brain connectivity in schizophrenia.
Review in Frontiers in human neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 155 citations in OpenAlex.
- Quantitative analysis of literature on diagnostic biomarkers of Schizophrenia: revealing research hotspots and future prospects.BMC psychiatry · 2025Pooled it
- Inter- and intra-hemispheric lateralization alterations in auditory verbal hallucinations of Schizophrenia: insights from resting-state functional connectivity.European archives of psychiatry and clinical neuroscience · 2026Article
- A comprehensive investigation into EEG spectral analysis for ADHD brain dominance.AIMS neuroscience · 2026Article
- Schizophrenia.Nature reviews. Disease primers · 2025Review
- Multimodal prediction of psychotic-like experiences using elastic net modeling: external validation in a clinical sample.Psychological medicine · 2025Article
- Asymmetry of attentive networks contributes to adult Attention-deficit/hyperactivity disorder (ADHD) pathophysiology.European archives of psychiatry and clinical neuroscience · 2025Article
- Altered Hemispheric Asymmetry of Functional Hierarchy in Schizophrenia.Brain sciences · 2025Article
- Structural and functional connectivity in relation to executive functions in antipsychotic-naïve patients with first episode schizophrenia and levels of glutamatergic metabolites.Schizophrenia (Heidelberg, Germany) · 2024Article
- Edge Density Imaging Identifies White Matter Biomarkers of Late-Life Obesity and Cognition.Aging and disease · 2024Article
- Modulation of hemispheric asymmetry in executive control of attention in schizophrenia with atypical antipsychotic treatment: Potential benefits of olanzapine.Schizophrenia research. Cognition · 2024Article
- A new perspective on positive symptoms: expression of damage or self-defence mechanism of the brain?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Machine learning in small sample neuroimaging studies: Novel measures for schizophrenia analysis.Human brain mapping · 2024Article
- Pharmaco-EEG of antipsychotic treatment response: a systematic review.Schizophrenia (Heidelberg, Germany) · 2023Review
- Clinical and biological correlates of optical coherence tomography findings in schizophrenia.European archives of psychiatry and clinical neuroscience · 2023Article
- Receptor-Independent Therapies for Forensic Detainees with Schizophrenia-Dementia Comorbidity.International journal of molecular sciences · 2023Article
- Lateralization of major white matter tracts during infancy is time-varying and tract-specific.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Cognitive Processes and Resting-State Functional Neuroimaging Findings in High Schizotypal Individuals and Schizotypal Personality Disorder Patients: A Systematic Review.Brain sciences · 2023Review
- Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- MFCSC: Novel method to calculate mismatch between functional and structural brain connectomes, and its application for detecting hemispheric functional specialisations.Scientific reports · 2023Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, a growing body of data has revealed that beyond a dysfunction of connectivity among different brain areas in schizophrenia patients (SCZ), there is also an abnormal asymmetry of functional connectivity compared with healthy subjects. The loss of the cerebral torque and the abnormalities of gyrification, with an increased or more complex cortical folding in the right hemisphere may provide an anatomical basis for such aberrant connectivity in SCZ. Furthermore, diffusion tensor imaging studies have shown a significant reduction of leftward asymmetry in some key white-matter tracts in SCZ. In this paper, we review the studies that investigated both structural brain asymmetry and asymmetry of functional connectivity in healthy subjects and SCZ. From an analysis of the existing literature on this topic, we can hypothesize an overall generally attenuated asymmetry of functional connectivity in SCZ compared to healthy controls. Such attenuated asymmetry increases with the duration of the disease and correlates with psychotic symptoms. Finally, we hypothesize that structural deficits across the corpus callosum may contribute to the abnormal asymmetry of intra-hemispheric connectivity in schizophrenia.
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