ReviewFrontiers in systems neuroscience2014
Individual differences in response to positive and negative stimuli: endocannabinoid-based insight on approach and avoidance behaviors.
Review in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Individual differences in emotional reactivity: A multidimensional systematic review across the big five.PloS one · 2026Pooled it
- Enhanced proactive control under stress: divergent neural dynamics of social vs. Monetary rewards in table tennis athletes.Frontiers in sports and active living · 2025Article
- Network-based mapping and neurotransmitter architecture of brain gray matter correlates of extraversion.Frontiers in systems neuroscience · 2025Article
- The Impact of Ageing on Episodic Memory Retrieval: How Valence Influences Neural Functional Connectivity.NeuroSci · 2024Article
- Investigate Effects of Music Therapy on Functional Connectivity in Papez Circuit of Breast Cancer Patients Using fMRI.Brain topography · 2024Article
- Neuroinflammation in the prefrontal-amygdala-hippocampus network is associated with maladaptive avoidance behaviour.Heliyon · 2024Article
- Transcriptomic and Network Analyses Reveal Immune Modulation by Endocannabinoids in Approach/Avoidance Traits.International journal of molecular sciences · 2022Article
- Arousability, Personality, and Decision-Making Ability in Dissociative Disorder.Indian journal of psychological medicine · 2021Article
- Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders.Molecular psychiatry · 2021Article
- Oxytocin and Addiction: Potential Glutamatergic Mechanisms.International journal of molecular sciences · 2021Review
- Cerebellar BDNF Promotes Exploration and Seeking for Novelty.The international journal of neuropsychopharmacology · 2018Article
- The verbal nature of worry in generalized anxiety: Insights from the brain.NeuroImage. Clinical · 2018Article
- Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit.Scientific reports · 2016Article
- Editorial: Individual differences: from neurobiological bases to new insight on approach and avoidance behavior.Frontiers in systems neuroscience · 2015Article
- Relationship between peripheral blood dopamine level and internet addiction disorder in adolescents: a pilot study.International journal of clinical and experimental medicine · 2015Article
- The State of Digital Biomarkers in Mental Health.Digital biomarkersArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approach and avoidance behaviors-the primary responses to the environmental stimuli of danger, novelty and reward-are associated with the brain structures that mediate cognitive functionality, reward sensitivity and emotional expression. Individual differences in approach and avoidance behaviors are modulated by the functioning of amygdaloid-hypothalamic-striatal and striatal-cerebellar networks implicated in action and reaction to salient stimuli. The nodes of these networks are strongly interconnected and by acting on them the endocannabinoid and dopaminergic systems increase the intensity of appetitive or defensive motivation. This review analyzes the approach and avoidance behaviors in humans and rodents, addresses neurobiological and neurochemical aspects of these behaviors, and proposes a possible synaptic plasticity mechanism, related to endocannabinoid-dependent long-term potentiation (LTP) and depression that allows responding to salient positive and negative stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.