ArticleFrontiers in systems neuroscience2014
Sleep memory processing: the sequential hypothesis.
Article in Frontiers in systems neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Sleep deprivation and memory: Meta-analytic reviews of studies on sleep deprivation before and after learning.Psychological bulletin · 2021Pooled it
- Promoting memory consolidation during sleep: A meta-analysis of targeted memory reactivation.Psychological bulletin · 2020Pooled it
- Emotional Processing in a Nap Paradigm: The Role of Sleep Stages in Memory and Reactivity.Psychophysiology · 2026Article
- REM sleep favors the restructuring of problem-related semantic associations.Communications biology · 2026Article
- Adaptive consolidation of active inference: excitatory and inhibitory mechanisms for organizing feedforward and feedback memory systems in sleep.Cerebral cortex (New York, N.Y. : 1991) · 2025Review
- Both slow wave and rapid eye movement sleep contribute to emotional memory consolidation.Communications biology · 2025Article
- Does sleep benefit source memory? Investigating 12-h retention intervals with a multinomial modeling approach.Memory & cognition · 2025Article
- Targeted memory reactivation during sleep improves emotional memory modulation following imagery rescripting.Translational psychiatry · 2024Article
- Activity-Based Prospective Memory and Motor Sleep Inertia in Insomnia.Brain sciences · 2024Article
- Activity-Based Prospective Memory in Insomniacs.Sensors (Basel, Switzerland) · 2024Article
- Engram mechanisms of memory linking and identity.Nature reviews. Neuroscience · 2024Review
- Article
- REM disruption and REM Vagal Activity Predict Extinction Recall in Trauma-Exposed Individuals.bioRxiv : the preprint server for biology · 2024Article
- Motor learning- and consolidation-related resting state fast and slow brain dynamics across wake and sleep.Scientific reports · 2024Article
- The consequences of sleep deprivation on cognitive performance.Neurosciences (Riyadh, Saudi Arabia) · 2023Review
- Longitudinal trajectories of spectral power during sleep in middle-aged and older adults.Aging brain · 2023Article
- Memory loss at sleep onset.Cerebral cortex communications · 2022Article
- Sleep, Cognition and Cortisol in Addison's Disease: A Mechanistic Relationship.Frontiers in endocrinology · 2021Review
- Molecular Mechanisms of Memory Consolidation That Operate During Sleep.Frontiers in molecular neuroscience · 2021Review
- Nightmares and the Cannabinoids.Current neuropharmacology · 2020Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the sequential hypothesis (SH) memories acquired during wakefulness are processed during sleep in two serial steps respectively occurring during slow wave sleep (SWS) and rapid eye movement (REM) sleep. During SWS memories to be retained are distinguished from irrelevant or competing traces that undergo downgrading or elimination. Processed memories are stored again during REM sleep which integrates them with preexisting memories. The hypothesis received support from a wealth of EEG, behavioral, and biochemical analyses of trained rats. Further evidence was provided by independent studies of human subjects. SH basic premises, data, and interpretations have been compared with corresponding viewpoints of the synaptic homeostatic hypothesis (SHY). Their similarities and differences are presented and discussed within the framework of sleep processing operations. SHY's emphasis on synaptic renormalization during SWS is acknowledged to underline a key sleep effect, but this cannot marginalize sleep's main role in selecting memories to be retained from downgrading traces, and in their integration with preexisting memories. In addition, SHY's synaptic renormalization raises an unsolved dilemma that clashes with the accepted memory storage mechanism exclusively based on modifications of synaptic strength. This difficulty may be bypassed by the assumption that SWS-processed memories are stored again by REM sleep in brain subnuclear quantum particles. Storing of memories in quantum particles may also occur in other vigilance states. Hints are provided on ways to subject the quantum hypothesis to experimental tests.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.