ArticleFrontiers in neuroanatomy2014
Dynamic expression of Notch-dependent neurogenic markers in the chick embryonic nervous system.
Article in Frontiers in neuroanatomy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- The transcriptional landscape of the developing chick trigeminal ganglion.Developmental biology · 2025Article
- Decoding the spatiotemporal regulation of transcription factors during human spinal cord development.Cell research · 2024Article
- Multiomics analysis identifies novel facilitators of human dopaminergic neuron differentiation.EMBO reports · 2024Article
- A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus.eLife · 2023Article
- Neurodegenerative Disorder Risk in Krabbe Disease Carriers.International journal of molecular sciences · 2022Article
- Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer.Cell systems · 2022Article
- Using bioinformatics and systems biology to discover common pathogenetic processes between sarcoidosis and COVID-19.Gene reports · 2022Article
- Development of the basal hypothalamus through anisotropic growth.Journal of neuroendocrinology · 2019Review
- Hedgehog Signaling Promotes the Proliferation and Subsequent Hair Cell Formation of Progenitor Cells in the Neonatal Mouse Cochlea.Frontiers in molecular neuroscience · 2017Article
- Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain.Neural development · 2016Article
- The DNA methylation profile of activated human natural killer cells.Epigenetics · 2016Article
- Changes in gene expression and cell shape characterise stages of epibranchial placode-derived neuron maturation in the chick.Journal of anatomy · 2015Article
- Identification of neuron-related genes for cell therapy of neurological disorders by network analysis.Journal of Zhejiang University. Science. BArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The establishment of a functional nervous system requires a highly orchestrated process of neural proliferation and differentiation. The evolutionary conserved Notch signaling pathway is a key regulator of this process, regulating basic helix-loop-helix (bHLH) transcriptional repressors and proneural genes. However, little is known about downstream Notch targets and subsequently genes required for neuronal specification. In this report, the expression pattern of Transgelin 3 (Tagln3), Chromogranin A (Chga) and Contactin 2 (Cntn2) was described in detail during early chick embryogenesis. Expression of these genes was largely restricted to the nervous system including the early axon scaffold populations, cranial ganglia and spinal motor neurons. Their temporal and spatial expression were compared with the neuronal markers Nescient Helix-Loop-Helix 1 (Nhlh1), Stathmin 2 (Stmn2) and HuC/D. We show that Tagln3 is an early marker for post-mitotic neurons whereas Chga and Cntn2 are expressed in mature neurons. We demonstrate that inhibition of Notch signaling during spinal cord neurogenesis enhances expression of these markers. This data demonstrates that Tagln3, Chga and Cntn2 represent strong new candidates to contribute to the sequential progression of vertebrate neurogenesis.
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