Evidence map›Paper›PMID 25565963›Full record

ReviewFrontiers in cellular neuroscience2014

Diffuse axonal injury in brain trauma: insights from alterations in neurofilaments.

Declan G Siedler, Meng Inn Chuah, Matthew T K Kirkcaldie, James C Vickers, Anna E King

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 2 syntheses or guidelines pooled it, 111 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Declan G SiedlerWicking Dementia Research and Education Centre, Medical Sciences Precinct Hobart, TAS, Australia ; School of Medicine, University of Tasmania Hobart, TAS, Australia.
Meng Inn ChuahWicking Dementia Research and Education Centre, Medical Sciences Precinct Hobart, TAS, Australia ; School of Medicine, University of Tasmania Hobart, TAS, Australia.
Matthew T K KirkcaldieWicking Dementia Research and Education Centre, Medical Sciences Precinct Hobart, TAS, Australia ; School of Medicine, University of Tasmania Hobart, TAS, Australia.
James C VickersWicking Dementia Research and Education Centre, Medical Sciences Precinct Hobart, TAS, Australia ; School of Medicine, University of Tasmania Hobart, TAS, Australia.
Anna E KingWicking Dementia Research and Education Centre, Medical Sciences Precinct Hobart, TAS, Australia ; School of Medicine, University of Tasmania Hobart, TAS, Australia.
University of Tasmania · AUWicking Dementia Centre

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) from penetrating or closed forces to the cranium can result in a range of forms of neural damage, which culminate in mortality or impart mild to significant neurological disability. In this regard, diffuse axonal injury (DAI) is a major neuronal pathophenotype of TBI and is associated with a complex set of cytoskeletal changes. The neurofilament triplet proteins are key structural cytoskeletal elements, which may also be important contributors to the tensile strength of axons. This has significant implications with respect to how axons may respond to TBI. It is not known, however, whether neurofilament compaction and the cytoskeletal changes that evolve following axonal injury represent a component of a protective mechanism following damage, or whether they serve to augment degeneration and progression to secondary axotomy. Here we review the structure and role of neurofilament proteins in normal neuronal function. We also discuss the processes that characterize DAI and the resultant alterations in neurofilaments, highlighting potential clues to a possible protective or degenerative influence of specific neurofilament alterations within injured neurons. The potential utility of neurofilament assays as biomarkers for axonal injury is also discussed. Insights into the complex alterations in neurofilaments will contribute to future efforts in developing therapeutic strategies to prevent, ameliorate or reverse neuronal degeneration in the central nervous system (CNS) following traumatic injury.

Indexed as

biomarkersdiffuse axonal injurydiffuse brain traumaneurofilamentneurofilament compactionNFLtraumatic axonal injurytraumatic brain injury

Identifiers

PMID25565963
PMCPMC4269130
OpenAlexW2115057514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.