ReviewFrontiers in neuroscience2014
Cytokine variations and mood disorders: influence of social stressors and social support.
Review in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Does psychological treatment of major depression reduce cardiac risk biomarkers? An exploratory randomized controlled trial.Psychological medicine · 2023Trial
- The relationship between heart rate variability and affective disorders: associations with symptomatic improvement and therapeutic alliance.BMC psychology · 2025Article
- Pregnant Women Chronically Infected byPathogens (Basel, Switzerland) · 2025Article
- Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction.Brain sciences · 2024Review
- Correlation of Specific Inflammatory Markers With the Occurrence of Depression in Patients With Psoriasis and Their Use as Biomarkers for the Diagnosis of Depression.Dermatology practical & conceptual · 2024Article
- Impact of social distancing from the COVID-19 pandemic on the immuno-inflammatory response of older adults.BMC geriatrics · 2024Article
- Social Isolation Stress Modulates Pregnancy Outcomes and the Inflammatory Profile of Rat Uterus.International journal of molecular sciences · 2022Article
- Fluctuations in quality of life and immune responses during intravenous immunoglobulin infusion cycles.PloS one · 2022Article
- Loneliness: An Immunometabolic Syndrome.International journal of environmental research and public health · 2021Review
- Transdiagnostic biomarker approaches to mental health disorders: Consideration of symptom complexity, comorbidity and context.Brain, behavior, & immunity - health · 2021Article
- Altered immunoemotional regulatory system in COVID-19: From the origins to opportunities.Journal of neuroimmunology · 2021Review
- Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation.NPJ microgravity · 2021Article
- Chronic Neuroinflammation Induced by Lipopolysaccharide Injection into the Third Ventricle Induces Behavioral Changes.Journal of molecular neuroscience : MN · 2021Article
- Interplay between social isolation and loneliness and chronic systemic inflammation during the COVID-19 pandemic in Japan: Results from U-CORONA study.Brain, behavior, and immunity · 2021Article
- Fitness Shifts the Balance of BDNF and IL-6 from Inflammation to Repair among People with Progressive Multiple Sclerosis.Biomolecules · 2021Article
- Neurological Mechanisms of Animal-Assisted Intervention in Alzheimer's Disease: A Hypothetical Review.Frontiers in aging neuroscience · 2021Review
- Impact of a natural disaster on access to care and biopsychosocial outcomes among Hispanic/Latino cancer survivors.Scientific reports · 2020Article
- Resilience: Safety in the Aftermath of Traumatic Stressor Experiences.Frontiers in behavioral neuroscience · 2020Review
- Article
- A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications.Frontiers in behavioral neuroscience · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stressful events have been implicated in the evolution of mood disorders. In addition to brain neurotransmitters and growth factors, the view has been offered that these disorders might be provoked by the activation of the inflammatory immune system as well as by de novo changes of inflammatory cytokines within the brain. The present review describes the impact of social stressors in animals and in humans on behavioral changes reminiscent of depressive states as well as on cytokine functioning. Social stressors increase pro-inflammatory cytokines in circulation as well as in brain regions that have been associated with depression, varying with the animal's social status and/or behavioral methods used to contend with social challenges. Likewise, in humans, social stressors that favor the development of depression are accompanied by elevated circulating cytokine levels and conversely, conditions that limit the cytokine elevations correlated with symptom attenuation or reversal. The implications of these findings are discussed in relation to the potentially powerful effects of social support, social identity, and connectedness in maintaining well-being and in diminishing symptoms of depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.