ReviewFrontiers in neuroscience2014
Functional network alterations and their structural substrate in drug-resistant epilepsy.
Review in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 84 citations in OpenAlex.
- Individual-specific resting-state networks predict language dominance in drug-resistant epilepsy.Epilepsia · 2026Article
- The use of automated and AI-driven algorithms for the detection of hippocampal sclerosis and focal cortical dysplasia.Epilepsia · 2025Review
- Mapping human thalamocortical connectivity with electrical stimulation and recording.Nature neuroscience · 2025Article
- Brain Connectivity Yields Insights into the Pathogenesis of Epilepsy and Subtypes: Evidence from Mendelian Randomization Analysis.Health data science · 2025Article
- Brain Networks for Cortical Atrophy and Responsive Neurostimulation in Temporal Lobe Epilepsy.JAMA neurology · 2024Article
- Mapping Functional Connectivity Signatures of Pharmacoresistant Focal Cortical Dysplasia-Related Epilepsy.Annals of neurology · 2024Article
- Causal Cortical and Thalamic Connections in the Human Brain.bioRxiv : the preprint server for biology · 2024Article
- How fast does the brain recover after an epileptic seizure?Annals of clinical and translational neurology · 2024Article
- Article
- Limbic network co-localization predicts pharmacoresistance in dysplasia-related epilepsy.Annals of clinical and translational neurology · 2023Article
- Evaluating whole-brain tissue-property changes in MRI-negative pharmacoresistant focal epilepsies using MR fingerprinting.Epilepsia · 2023Article
- Subcortical Functional Connectivity Gradients in Temporal Lobe Epilepsy.medRxiv : the preprint server for health sciences · 2023Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Episodic memory network connectivity in temporal lobe epilepsy.Epilepsia · 2022Article
- Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies.Network neuroscience (Cambridge, Mass.) · 2022Article
- Dynamical Network Models From EEG and MEG for Epilepsy Surgery-A Quantitative Approach.Frontiers in neurology · 2022Review
- Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy.Nature reviews. Neurology · 2021Review
- Widespread cortical dyslamination in epilepsy patients with malformations of cortical development.Neuroradiology · 2021Article
- Regional abnormality of functional connectivity is associated with clinical manifestations in individuals with intractable focal epilepsy.Scientific reports · 2021Article
- Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia.NeuroImage. Clinical · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The advent of MRI has revolutionized the evaluation and management of drug-resistant epilepsy by allowing the detection of the lesion associated with the region that gives rise to seizures. Recent evidence indicates marked chronic alterations in the functional organization of lesional tissue and large-scale cortico-subcortical networks. In this review, we focus on recent methodological developments in functional MRI (fMRI) analysis techniques and their application to the two most common drug-resistant focal epilepsies, i.e., temporal lobe epilepsy related to mesial temporal sclerosis and extra-temporal lobe epilepsy related to focal cortical dysplasia. We put particular emphasis on methodological developments in the analysis of task-free or "resting-state" fMRI to probe the integrity of intrinsic networks on a regional, inter-regional, and connectome-wide level. In temporal lobe epilepsy, these techniques have revealed disrupted connectivity of the ipsilateral mesiotemporal lobe, together with contralateral compensatory reorganization and striking reconfigurations of large-scale networks. In cortical dysplasia, initial observations indicate functional alterations in lesional, peri-lesional, and remote neocortical regions. While future research is needed to critically evaluate the reliability, sensitivity, and specificity, fMRI mapping promises to lend distinct biomarkers for diagnosis, presurgical planning, and outcome prediction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.