ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2015
Salivary glucose concentration exhibits threshold kinetics in normal-weight, overweight, and obese children.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The salivary microbiome is altered in the presence of a high salivary glucose concentration.PloS one · 2017Trial
- A User-Centered Approach in the Development of a Label-Free Impedimetric Chemiresistor for HACS omega · 2026Article
- Oral microbiome classification of elevated salivary glucose in a large adolescent Kuwaiti population.Frontiers in microbiology · 2026Article
- Correlation of serum biochemical parameters and saliva pH in healthy individuals.Saudi journal of biological sciences · 2023Article
- Salivary N1-Methyl-2-Pyridone-5-Carboxamide, a Biomarker for Uranium Uptake, in Kuwaiti Children Exhibiting Exceptional Weight Gain.Frontiers in endocrinology · 2019Article
- Salivary glucose as a non-invasive biomarker of type 2 diabetes mellitus.Journal of clinical and experimental dentistry · 2018Article
- Capsule Prolongs Survival of Streptococcus pneumoniae during Starvation.Infection and immunity · 2018Article
- Caveolin-1 Variant Is Associated With the Metabolic Syndrome in Kuwaiti Children.Frontiers in genetics · 2018Article
- Association of blood glucose and lipid levels with complete blood count indices to establish a regression model.Biomedical reports · 2017Article
- Unhealthy Phenotype as Indicated by Salivary Biomarkers: Glucose, Insulin, VEGF-A, and IL-12p70 in Obese Kuwaiti Adolescents.Journal of obesity · 2016Article
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10 authors.
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Abstract
backgroundMetabolic syndrome in childhood predicts the development of cardiovascular disease and type 2 diabetes (T2D) in adulthood. Testing for features of metabolic syndrome, such as fasting plasma glucose concentration, requires blood sampling which can be difficult in children. Here we evaluated salivary glucose concentration as a surrogate measurement for plasma glucose concentration in 11-year-old US children.
methodsChildren from Portland, Maine, and Cambridge, Massachusetts, with a mean age of 10.6±0.2 years provided 6-hour fasting samples of both blood and whole saliva. Salivary glucose levels were measured with a high-sensitivity assay (sensitivity =0.002 mg/dL). Plasma glucose levels were determined by a commercial clinical laboratory. Blood pressure, salivary flow rate, height, and weight were also measured.
resultsOf the 65 children enrolled, there were two underweight children (3.1%), 30 normal-weight children (46.2%), 12 overweight children (18.4%), and 21 obese children (32.3%). The mean overall glucose concentrations were 0.11±0.02 mg/dL in saliva and 86.3±0.8 mg/dL in plasma, and these did not differ significantly by body-weight groups. By regression analysis, the plasma concentration equaled 13.5 times the saliva concentration, with a threshold level of 84.8 mg/dL. Salivary glucose values less than threshold plasma concentration were essentially zero. Diagnostic analysis indicated a positive predictive value of 50%, a negative predictive value of 90%, and a sensitivity and specificity both of approximately 75%. The salivary glucose concentration did not vary with saliva flow rate.
conclusionTaking into account the threshold response characteristics of the salivary glucose concentration response, these results suggest that testing salivary glucose levels may be useful as a screening assay for high fasting plasma glucose levels. The low false positive value is important to assure a low fraction of missed diagnoses.
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