ArticleInternational journal of nanomedicine2014
Evaluation of silica nanoparticle toxicity after topical exposure for 90 days.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- Gestational Intranasal Exposure to Silicon Dioxide Nanoparticles in Rats.International journal of nanomedicine · 2026Article
- Skin Microbiome, Nanotoxicology, and Regulatory Gaps: Chronic Cosmetic Exposure and Skin Barrier Dysfunction-A Systematic Review.Pharmaceutics · 2025Review
- Synthetic amorphous silica: MAK Value Documentation, addendum - Translation of the German version from 2023.The MAK collection for occupational health and safety · 2025Review
- Comment on Balwierz et al. Potential Carcinogens in Makeup Cosmetics.International journal of environmental research and public health · 2024Article
- A Review of the Antibacterial, Fungicidal and Antiviral Properties of Selenium Nanoparticles.Materials (Basel, Switzerland) · 2023Review
- Potential Carcinogens in Makeup Cosmetics.International journal of environmental research and public health · 2023Article
- Copper nano-architecture topical cream for the accelerated recovery of burnt skin.Nanoscale advances · 2023Article
- The Study of Nanosized Silicate-Substituted Hydroxyapatites Co-Doped with SrCurrent issues in molecular biology · 2022Article
- In Vivo Application of Silica-Derived Inks for Bone Tissue Engineering: A 10-Year Systematic Review.Bioengineering (Basel, Switzerland) · 2022Review
- A toxicological profile of silica nanoparticles.Toxicology research · 2022Review
- Novasomes as Nano-Vesicular Carriers to Enhance Topical Delivery of Fluconazole: A New Approach to Treat Fungal Infections.Molecules (Basel, Switzerland) · 2022Article
- High Doses of Silica Nanoparticles Obtained by Microemulsion and Green Routes Compromise Human Alveolar Cells Morphology and Stiffness Differently.Bioinorganic chemistry and applications · 2022Article
- Nanocarrier-Mediated Topical Insulin Delivery for Wound Healing.Materials (Basel, Switzerland) · 2021Review
- Behavioural alterations induced by chronic exposure to 10 nm silicon dioxide nanoparticles.IET nanobiotechnology · 2021Article
- Understanding the mechanisms of silica nanoparticles for nanomedicine.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2021Review
- Hepatotoxicity induced by nanomaterials: mechanisms and in vitro models.Archives of toxicology · 2021Review
- Formulation of Tioconazole andMolecules (Basel, Switzerland) · 2020Article
- Toxicologic Evaluation for Amorphous Silica Nanoparticles: Genotoxic and Non-Genotoxic Tumor-Promoting Potential.Pharmaceutics · 2020Article
- Silica Nanoparticles-A Versatile Tool for the Treatment of Bacterial Infections.Frontiers in chemistry · 2020Review
- Amorphous silicon dioxide nanoparticles modulate immune responses in a model of allergic contact dermatitis.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs) were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.